Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells.

@article{Shi1999OrallyIP,
  title={Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells.},
  author={Hai Ning Shi and M. J. Grusby and Cathryn Nagler-Anderson},
  journal={Journal of immunology},
  year={1999},
  volume={162 9},
  pages={5143-8}
}
Intragastric administration of soluble protein Ags results in peripheral tolerance to the fed Ag. To examine the role of cytokine regulation in the induction of oral tolerance, we fed OVA to mice deficient in Th1 (Stat 4-/-) and Th2 (Stat 6-/-) cells and compared their response to that of normal BALB/c controls. We found that, in spite of these deficiencies, OVA-specific peripheral cell-mediated and humoral nonresponsiveness was maintained in both Stat 4-/- and Stat 6-/- mice. In the mucosa… CONTINUE READING
16 Citations
37 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Oral tolerance: physiological basis and clinical applications

  • A. M. Mowat, H. L. Weiner
  • Mucosal Immunology .
  • 1999

Similar Papers

Loading similar papers…