Orally effective CVS-1123 prevents coronary artery thrombosis in the conscious dog.

@article{Cousins1996OrallyEC,
  title={Orally effective CVS-1123 prevents coronary artery thrombosis in the conscious dog.},
  author={G. Cousins and G. Friedrichs and Y. Sudo and S. Rebello and W. Rote and G. Vlasuk and T. Nolan and C. Mendoza and B. Lucchesi},
  journal={Circulation},
  year={1996},
  volume={94 7},
  pages={
          1705-12
        }
}
  • G. Cousins, G. Friedrichs, +6 authors B. Lucchesi
  • Published 1996
  • Medicine
  • Circulation
  • BACKGROUND We examined the oral efficacy of a direct thrombin inhibitor, CVS-1123 [(CH3CH2CH2)(2)-CH-CO-Asp (OCH3)-Pro-Arg-CHO; MW, 575]. The object was to determine whether thrombin inhibition could reduce the incidence of occlusive coronary artery thrombosis in response to arterial wall injury. METHODS AND RESULTS Arterial wall injury was induced in conscious dogs by a 150-muA anodal current applied to the intimal surface of the circumflex coronary artery 30 minutes after oral CVS-1123 (20… CONTINUE READING
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