Orally delivered methadone as a reinforcer for rhesus monkeys: the relationship between drug concentration and choice.

Abstract

The relative reinforcing effects of orally delivered methadone were studied in five male rhesus monkeys. Drug deliveries were available under either a fixed-ratio (FR) or a fixed-interval (FI) schedule. Three concentrations of methadone, low (0.05 mg/ml), intermediate (0.2 mg/ml), and high (0.8 mg/ml) were delivered in 0.65 ml volumes. In the first… (More)

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@article{Meisch1996OrallyDM, title={Orally delivered methadone as a reinforcer for rhesus monkeys: the relationship between drug concentration and choice.}, author={R. A. Meisch and R. B. Stewart and N. S. Wang}, journal={Pharmacology, biochemistry, and behavior}, year={1996}, volume={54 3}, pages={547-54} }