Orally available cidofovir derivative active against smallpox

  title={Orally available cidofovir derivative active against smallpox},
  author={Jane Bradbury},
  journal={The Lancet},
Smallpox vaccine: contraindications, administration, and adverse reactions.
Since the terrorist attacks of September 11, 2001, and the anthrax exposures in the following weeks, concern that smallpox could be used as a biologic weapon has increased. Public health departments
Evaluation of 21 st-Century Risks of Smallpox Vaccination and Policy Options
This paper reviews the clinical presentations of major adverse events after vaccination and the rates of occurrence of these events observed in the 1960s and concludes immunization of medical workers is sufficient in the absence of a known threat of a bioterrorist attack or the identification of a smallpox-infected person.
Evaluation of 21st-Century Risks of Smallpox Vaccination and Policy Options
The smallpox vaccine is described; risks from vaccination, as observed in the 1960s are reviewed; the actual number of deaths from vaccination that might occur after widespread vaccination today are estimated; and the risk for spread of smallpox from a bioterrorism attack is reviewed.
Issues in preparedness for biologic terrorism: a perspective for critical care nursing.
The essential details of the presentation, diagnosis, treatment, and prophylaxis of the biological warfare agents that merit greatest concern are provided, and five biological Warfare agents of particular interest are described in detail.
Broad spectrum antiviral nucleosides—Our best hope for the future
Smallpox: anything to declare?
An overview of the World Health Organization's spectacular success in achieving the eradication of smallpox is provided and how variola virus could potentially re-emerge and how prepared the authors are to counter such a re-emergence is discussed.
Adverse events occurring after smallpox vaccination.
From actually toxic to highly specific – novel drugs against poxviruses
The latest anti-poxvirus drugs are kinase inhibitors, which were originally developed to treat cancer progression but in addition block egress of poxviruses from infected cells.