Orally available cidofovir derivative active against smallpox

@article{Bradbury2002OrallyAC,
  title={Orally available cidofovir derivative active against smallpox},
  author={Jane Bradbury},
  journal={The Lancet},
  year={2002},
  volume={359}
}
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18 Citations
Background Citations
7
Methods Citations
1

18 Citations

Citation Type

Citation Type

Topical cidofovir for the treatment of dermatologic conditions: verruca, condyloma, intraepithelial neoplasia, herpes simplex and its potential use in smallpox.
Smallpox vaccine: contraindications, administration, and adverse reactions.
Since the terrorist attacks of September 11, 2001, and the anthrax exposures in the following weeks, concern that smallpox could be used as a biologic weapon has increased. Public health departments…
Evaluation of 21 st-Century Risks of Smallpox Vaccination and Policy Options
TLDR
This paper reviews the clinical presentations of major adverse events after vaccination and the rates of occurrence of these events observed in the 1960s and concludes immunization of medical workers is sufficient in the absence of a known threat of a bioterrorist attack or the identification of a smallpox-infected person.
Evaluation of 21st-Century Risks of Smallpox Vaccination and Policy Options
TLDR
The smallpox vaccine is described; risks from vaccination, as observed in the 1960s are reviewed; the actual number of deaths from vaccination that might occur after widespread vaccination today are estimated; and the risk for spread of smallpox from a bioterrorism attack is reviewed.
The efficacy of cidofovir treatment of mice infected with ectromelia (mousepox) virus encoding interleukin-4.
Issues in preparedness for biologic terrorism: a perspective for critical care nursing.
TLDR
The essential details of the presentation, diagnosis, treatment, and prophylaxis of the biological warfare agents that merit greatest concern are provided, and five biological Warfare agents of particular interest are described in detail.
Broad spectrum antiviral nucleosides—Our best hope for the future
Smallpox: anything to declare?
TLDR
An overview of the World Health Organization's spectacular success in achieving the eradication of smallpox is provided and how variola virus could potentially re-emerge and how prepared the authors are to counter such a re-emergence is discussed.
Adverse events occurring after smallpox vaccination.
From actually toxic to highly specific – novel drugs against poxviruses
TLDR
The latest anti-poxvirus drugs are kinase inhibitors, which were originally developed to treat cancer progression but in addition block egress of poxviruses from infected cells.
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