Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals.

@article{Miller1994OrallyAM,
  title={Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals.},
  author={Ariel Miller and Ofer Lider and Oded Abramsky and Howard L. Weiner},
  journal={European journal of immunology},
  year={1994},
  volume={24 5},
  pages={1026-32}
}
Antigen-driven tolerance is an effective method for suppression of autoimmune diseases. Adult animals can be tolerized against the induction of experimental autoimmune encephalomyelitis (EAE) by both oral and parenteral administration of myelin basic protein (MBP). We have found that in contrast to previous studies of neonatal tolerance in which parenterally administered autoantigens induced tolerance, the oral administration of MBP in neonatal rats did not result in tolerization to MBP, but… CONTINUE READING

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