Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2/HO-1 and Akt/mTOR pathways.

@article{Sahin2014OrallyAL,
  title={Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2/HO-1 and Akt/mTOR pathways.},
  author={Kazim Sahin and Cemal Orhan and Mehmet Tuzcu and Nurhan Şahin and Shakir Ali and Ibrahim Halil Bahçecioğlu and Osman Gokhan Guler and Ibrahim Hanifi Ozercan and Necip Ilhan and Omer N Kucuk},
  journal={Nutrition and cancer},
  year={2014},
  volume={66 4},
  pages={590-8}
}
Hepatocarcinogenesis is one of the most prevalent and lethal cancers. We studied the mechanisms underlying the inhibition of diethylnitrosamine (DEN)-induced hepatocarcinogenesis by lycopene in rats. Hepatocarcinogenesis was induced by an intraperitoneal injection of DEN followed by promotion with phenobarbital for 24 successive wk. The rats were given lycopene (20 mg/kg body weight) 3 times a week orally for 4 wk prior to initiation, and the treatment was continued for 24 consecutive wk… CONTINUE READING
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