Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions in ApoE-deficient mice.

@article{Matsumoto2008OrallyAE,
  title={Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions in ApoE-deficient mice.},
  author={Miwa Matsumoto and Masataka Sata and Daiju Fukuda and Kimie Tanaka and Masaaki Soma and Yasunobu Hirata and Ryozo Nagai},
  journal={Atherosclerosis},
  year={2008},
  volume={197 2},
  pages={524-33}
}
Accumulating evidence demonstrates that dietary intake of n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced incidence of cardiovascular events. However, the molecular mechanisms by which n-3 PUFAs prevent atherosclerosis are not fully understood. Here, we examined the effect of eicosapentaenoic acid (EPA), a major n-3 PUFA, on the pathogenesis of atherosclerosis in ApoE-deficient mice. Five-week-old ApoE-deficient male mice were fed on western-type diet supplemented with 5% (w… CONTINUE READING
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