Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis.

@article{Iigo2004OrallyAB,
  title={Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis.},
  author={Masaaki Iigo and Mariko Shimamura and Eiji Matsuda and Ken-Ichi Fujita and Hiroshi Nomoto and Jun Satoh and Syuji Kojima and David B. Alexander and Malcolm A. S. Moore and Hiroyuki Tsuda},
  journal={Cytokine},
  year={2004},
  volume={25 1},
  pages={36-44}
}
We have previously demonstrated that oral administration of bovine lactoferrin (bLF) markedly inhibits lung metastatic colony formation, and that this inhibition was possibly due to the activation of T and NK cells. Furthermore, we found that interleukin-18 (IL-18) is induced in epithelial cells of the small intestine by bLF. The present study was undertaken to confirm cytokine production in response to bLF and to assess the underlying mechanisms. Markedly elevated IL-18 levels were found in… CONTINUE READING

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