Orally administered apple procyanidins protect against experimental inflammatory bowel disease in mice.

@article{Yoshioka2008OrallyAA,
  title={Orally administered apple procyanidins protect against experimental inflammatory bowel disease in mice.},
  author={Yasuo Yoshioka and Hiroshi Akiyama and Masataka Nakano and Toshihiko Shoji and Tomomasa Kanda and Yasuyuki Ohtake and Toshichika Takita and Rieko Matsuda and Tamio Maitani},
  journal={International immunopharmacology},
  year={2008},
  volume={8 13-14},
  pages={
          1802-7
        }
}
Apple procyanidins (ACT) is a natural biologically active compound extracted from apple. Our recent studies have shown that ACT ameliorates the symptoms of atopic dermatitis and inhibits food-allergen-induced oral sensitization. The aim of this study was to investigate the potential protective effect and mechanism of action of ACT in a murine model of inflammatory bowel disease. We investigated the preventive effects of ACT in experimental models of colitis induced by dextran sulfate sodium… CONTINUE READING
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