Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice

Abstract

S-trans,trans-farnesylthiosalicylic acid (salirasib, FTS) is a synthetic small molecule that acts as a potent Ras inhibitor. Salirasib inhibits specifically both oncogenically activated Ras and growth factor receptor-mediated Ras activation, resulting in the inhibition of Ras-dependent tumor growth. The objectives of this study were to develop a sensitive… (More)
DOI: 10.1007/s00280-007-0451-6

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@article{Haklai2007OrallyAF, title={Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice}, author={Roni Haklai and Galit Elad-Sfadia and Yaakov Egozi and Yoel Kloog}, journal={Cancer Chemotherapy and Pharmacology}, year={2007}, volume={61}, pages={89-96} }