Orally active vasopressin V1a receptor antagonist, SRX251, selectively blocks aggressive behavior.

@article{Ferris2006OrallyAV,
  title={Orally active vasopressin V1a receptor antagonist, SRX251, selectively blocks aggressive behavior.},
  author={Craig F Ferris and Shi-fang Lu and Tara L Messenger and Christophe D Guillon and Ned D. Heindel and Marvin J Miller and Gary A Koppel and F Robert Bruns and Neal G. Simon},
  journal={Pharmacology, biochemistry, and behavior},
  year={2006},
  volume={83 2},
  pages={169-74}
}
Arginine vasopressin functions as a neurochemical signal in the brain to affect social behavior. There is an expanding literature from animal and human studies showing that vasopressin, through the vasopressin 1A receptor (V1A), can stimulate aggressive behavior. Using a novel monocylic beta lactam platform, a series of orally active vasopressin V1a antagonists was developed with high affinity for the human receptor. SRX251 was chosen from this series of V1a antagonists to screen for effects on… CONTINUE READING

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