Orally active-targeted drug delivery systems for proteins and peptides.

@article{Li2014OrallyAD,
  title={Orally active-targeted drug delivery systems for proteins and peptides.},
  author={Xiuying Li and Miaorong Yu and Weiwei Fan and Yong Gan and Lars Hovgaard and Mingshi Yang},
  journal={Expert opinion on drug delivery},
  year={2014},
  volume={11 9},
  pages={
          1435-47
        }
}
INTRODUCTION In the past decade, extensive efforts have been devoted to designing 'active targeted' drug delivery systems (ATDDS) to improve oral absorption of proteins and peptides. Such ATDDS enhance cellular internalization and permeability of proteins and peptides via molecular recognition processes such as ligand-receptor or antigen-antibody interaction, and thus enhance drug absorption. AREAS COVERED This review focuses on recent advances with orally ATDDS, including ligand-protein… CONTINUE READING
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