Orally active neurotrophin-enhancing agent protects against dysfunctions of the peripheral nerves in hyperglycemic animals.

@article{Kakinoki2006OrallyAN,
  title={Orally active neurotrophin-enhancing agent protects against dysfunctions of the peripheral nerves in hyperglycemic animals.},
  author={Bunpei Kakinoki and Sumito Sekimoto and Satoshi Yuki and Tetsuya Ohgami and Mikiko Sejima and Keiji Yamagami and Ken-ichi Saito},
  journal={Diabetes},
  year={2006},
  volume={55 3},
  pages={616-21}
}
Biological substances with neurotrophic activities, such as nerve growth factor (NGF) and monosialoganglioside GM1, have been considered as agents for diabetic peripheral neuropathy. Because recent studies have suggested that decreased availability of these substances might contribute to the pathogenesis of diabetic peripheral neuropathy, some clinical trials of NGF for diabetic peripheral neuropathy have been conducted and have led to mixed conclusions. The major reasons were its limited… CONTINUE READING