Orally active cephalosporins: synthesis, structure-activity relationships and oral absorption of 3-[(E) and (Z)-2-substituted vinyl]-cephalosporins.

@article{Yamamoto2000OrallyAC,
  title={Orally active cephalosporins: synthesis, structure-activity relationships and oral absorption of 3-[(E) and (Z)-2-substituted vinyl]-cephalosporins.},
  author={Hirofumi Yamamoto and Takeshi Terasawa and Atsushi Ohki and Fumiyuki Shirai and Kohji Kawabata and Kazuo Sakane and Satoru Matsumoto and Yoshimi Matsumoto and Shuichi Tawara},
  journal={Bioorganic & medicinal chemistry},
  year={2000},
  volume={8 1},
  pages={43-54}
}
A series of 7beta-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamid o]-3-[(E)- and (Z)-2-substituted vinyl]-3-cephem-4-carboxylic acids was designed and synthesized using palladium-catalyzed coupling reactions of a 3-methanesulfonyloxy-3-cephem and an E substituted vinyl stannane or Wittig reaction of a 3-triphenylphosphoniummethyl cephem and an aldehyde… CONTINUE READING