Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties : II . In Vivo Characterization in Rat Models of Inflammatory and Neuropathic Pain

@inproceedings{Pomonis2003OrallyEV,
  title={Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties : II . In Vivo Characterization in Rat Models of Inflammatory and Neuropathic Pain},
  author={James D Pomonis and James E Harrison and Lilly Mark and David R Bristol and Kenneth J. Valenzano and Katharine C. Walker},
  year={2003}
}
The vanilloid receptor 1 (VR1) is a cation channel expressed predominantly by nociceptive sensory neurons and is activated by a wide array of pain-producing stimuli, including capsaicin, noxious heat, and low pH. Although the behavioral effects of injected capsaicin and the VR1 antagonist capsazepine have indicated a potential role for VR1 in the generation and maintenance of persistent pain states, species differences in the molecular pharmacology of VR1 and a limited number of selective… CONTINUE READING
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