Oral xylose isomerase decreases breath hydrogen excretion and improves gastrointestinal symptoms in fructose malabsorption – a double‐blind, placebo‐controlled study

  title={Oral xylose isomerase decreases breath hydrogen excretion and improves gastrointestinal symptoms in fructose malabsorption – a double‐blind, placebo‐controlled study},
  author={P. Komericki and M. Akkilic-Materna and T. Strimitzer and K. Weyermair and H. Hammer and W. Aberer},
  journal={Alimentary Pharmacology \& Therapeutics},
Incomplete resorption of fructose results in increased colonic hydrogen production and is a frequent cause of abdominal symptoms. The only treatment available is diet. 
Review article: biological mechanisms for symptom causation by individual FODMAP subgroups ‐ the case for a more personalised approach to dietary restriction
The combination of five subgroups of poorly absorbed and rapidly fermented carbohydrates—fructans, galacto‐oligosaccharides, lactose, excess fructose and polyols—are thought to trigger gastrointestinal symptoms and are referred to collectively as “FODMAPs”. Expand
C URRENT OPINION Fructose malabsorption syndrome
Purpose of review Fructose malabsorption is associated with gastrointestinal symptoms. This review examines new findings on the physiology, assessment and therapy of fructose malabsorption inExpand
[Fructose and fructose intolerance].
The cornerstone of dietary management for fructose intolerance is the individual reduction of fructose intake and the FODMAP diet, led by a trained dietetician, and the newly introduced xylose-isomerase is efficient in reducing the symptoms of fructose intolerance. Expand
Fructose malabsorption syndrome
New insights into factors affecting fructose absorption may have therapeutic applications and Doubts surrounding clinical utility of fructose breath testing are emerging. Expand
Fermentable oligosaccharides, disaccharides, monosaccharides and polyols: role in irritable bowel syndrome
The ‘low fermentable oligosaccharide, disaccharides, monosacCharides and polyols diet’ has shown symptom improvement in 68–76% of patients and Randomized, controlled trials have now proven its efficacy. Expand
Update on Dietary Management of Childhood Functional Abdominal Pain Disorders.
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  • Medicine
  • Gastroenterology clinics of North America
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Diet plays a significant role for children with functional abdominal pain disorders andTherapies include carbohydrate (single and/or comprehensive) restriction, selective prebiotic and/ or enzyme supplementation. Expand
Dietary Fructose Intolerance, Fructan Intolerance and FODMAPs
While current research shows that the F ODMAP diet may be effective in treating some patients with irritable bowel syndrome, additional research is needed to identify more foods items that are high in FODMAPs, and to assess the long-term efficacy and safety of dietary interventions. Expand
Diagnosing and Treating Intolerance to Carbohydrates in Children
The most up-to-date research on intolerance to carbohydrates is examined, controversies relating to the diagnostic approach are discussed, including the role of molecular analysis, and new insights into modern management in the pediatric age are provided. Expand
The clinical value of breath hydrogen testing
The evidence suggests that breath hydrogen tests have limited clinical value in guiding clinical decision for the patient with a functional bowel disorder. Expand
Mistakes in the management of carbohydrate intolerance and how to avoid them
dose-independent reaction of the immune system that can affect many organs and systems, and in some cases can be life threatening. By contrast, the symptoms and clinical consequences of foodExpand


Comparison of the prevalence of fructose and lactose malabsorption across chronic intestinal disorders
Background  Fructose malabsorption, lactose malabsorption and an early rise in breath hydrogen after lactulose (ERBHAL) may play roles in induction of symptoms in gastrointestinal conditions.
Review article: fructose malabsorption and the bigger picture
Fructose is found widely in the diet as a free hexose, as the disaccharide, sucrose and in a polymerized form (fructans), which is not hydrolysed or absorbed in the small intestine. Expand
Review article: fructose in non‐alcoholic fatty liver disease
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  • Medicine
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The role of excess fructose intake in the pathogenesis of non‐alcoholic fatty liver disease (NAFLD) has recently received increasing attention, but the pathophysiology of this relationship has beenExpand
Diarrhea caused by carbohydrate malabsorption.
The role of the colon in the pathogenesis of diarrhea in carbohydrate mal absorption or physiologically incomplete absorption of carbohydrates, and on the most common manifestation of carbohydrate malabsorption, lactose mal absorption are focused on. Expand
Fructose-sorbitol malabsorption and symptom provocation in irritable bowel syndrome: relationship to enteric hypersensitivity and dysmotility.
Although carbohydrate malabsorption can provoke symptoms in some IBS patients, there is no consistent association between such a phenomenon and the presence of either jejunal hypersensitivity or dysmotility. Expand
Fructose Malabsorption May Be Gender Dependent and Fails to Show Compensation by Colonic Adaptation
It is concluded that gender may influence fructose malabsorption and there is no adaptation to regular consumption with basic fructose. Expand
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There is a dose-dependent and limited absorption capacity even in healthy individuals of fructose malabsorption, consistent with a facilitative transport system, and it is shown here by analysis of past studies on healthy adults that there is a significant relationship between fructose mal absorption and fructose dose. Expand
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Fructose is a potent reducing sugar that promotes the formation of toxic advanced glycation end-products, which appear to play a role in the aging process; in the pathogenesis of the vascular, renal, and ocular complications of diabetes; and in the development of atherosclerosis. Expand
Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults.
Fructose, in amounts commonly consumed, may result in mild gastrointestinal distress in normal people and those with gastrointestinal dysfunction and peak hydrogen levels and AUC were highly correlated, but neither was significantly related to symptoms. Expand
Colonic hydrogen absorption: quantification of its effect on hydrogen accumulation caused by bacterial fermentation of carbohydrates.
Colic hydrogen absorption is highly effective at low colonic hydrogen accumulation rates, but not at higher accumulation rates and future therapeutic approaches to the large interindividual variability in colonic gas accumulation after ingestion of poorly absorbable fermentable carbohydrates should be directed towards altering colonic bacterial metabolism. Expand