Oral vitamin K lowers the international normalized ratio more rapidly than subcutaneous vitamin K in the treatment of warfarin-associated coagulopathy. A randomized, controlled trial.

@article{Crowther2002OralVK,
  title={Oral vitamin K lowers the international normalized ratio more rapidly than subcutaneous vitamin K in the treatment of warfarin-associated coagulopathy. A randomized, controlled trial.},
  author={Mark Andrew Crowther and James Demetrios Douketis and Terri Schnurr and Luigi Steidl and Valentina Mera and Carolina Ultori and Achille Venco and Walter Ageno},
  journal={Annals of internal medicine},
  year={2002},
  volume={137 4},
  pages={251-4}
}
Context Giving vitamin K when stopping warfarin increases the rate at which the international normalized ratio (INR) returns to normal. Although many clinicians give vitamin K subcutaneously, it appears that oral vitamin K reduces INR more rapidly. Contribution This randomized, controlled trial compared oral with subcutaneous vitamin K for patients receiving warfarin who had an INR of 4.5 to 10.0 but no bleeding. Oral administration normalized the INR faster than the subcutaneous route… CONTINUE READING

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