Oral vanadyl sulfate in treatment of diabetes mellitus in rats.

  title={Oral vanadyl sulfate in treatment of diabetes mellitus in rats.},
  author={S Ramanadham and J J Mongold and Roger W. Brownsey and Gerard H. Cros and John Hugh McNeill},
  journal={The American journal of physiology},
  volume={257 3 Pt 2},
Recent reports have suggested that vanadium in the form of vanadyl (+IV) possesses insulin-like activity. Therefore, in the present study we examined the effects of administering oral vanadyl to diabetic animals. Wistar rats made diabetic with streptozotocin and age-matched controls were maintained for 10 wk in the absence and presence of vanadyl sulfate trihydrate in the drinking water. In the presence of vanadyl, decreases in rate of growth and circulating levels of insulin were the only… CONTINUE READING
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