Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06.

@article{Lembersky2006OralUA,
  title={Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06.},
  author={Barry C. Lembersky and H. Samuel Wieand and Nicholas J. Petrelli and Michael J O'connell and Linda H. Colangelo and Roy E. Smith and Thomas E. Seay and Jeffrey K. Giguere and M. Ernest Marshall and Andrew D. Jacobs and Lauren K. Colman and Atilla Soran and G. A. Yothers and Norman Wolmark},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 13},
  pages={
          2059-64
        }
}
PURPOSE The primary aim of this study was to compare the relative efficacy of oral uracil and tegafur (UFT) plus leucovorin (LV) with the efficacy of weekly intravenous fluorouracil (FU) plus LV in prolonging disease-free survival (DFS) and overall survival (OS) after primary surgery for colon carcinoma. PATIENTS AND METHODS Between February 1997 and March 1999, 1,608 patients with stage II and III carcinoma of the colon were randomly assigned to receive either oral UFT+LV or intravenous FU… CONTINUE READING

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