Oral tributyrin prevents endotoxin-induced lipid metabolism disorder.

Abstract

BACKGROUND & AIMS Sepsis leads to dysregulation of lipid and lipoprotein metabolism. Butyrate increases peroxisome proliferator-activated receptors (PPARs), which are key nuclear hormone receptors to induce fatty acid oxidation and synthesis. Oral administration of tributyrin, a prodrug of butyrate contained in dairy products, suppresses lipopolysaccharide… (More)
DOI: 10.1016/j.clnesp.2015.02.001

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