Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

  title={Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole},
  author={Anu Varhe and Klaus T. Olkkola and Pertti J. Neuvonen},
  journal={Clinical Pharmacology \& Therapeutics},
Triazolam is metabolized by CYP3A4 isozyme. Ketoconazole and itraconazole may seriously interact with some of the substrates of CYP3A4 (e.g., terfenadine); hence their possible interaction with triazolam in humans is important to uncover. 

Triazolam is ineffective in patients taking rifampin

Itraconazole increases plasma concentrations of quinidine

The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib

We investigated the effects of a strong CYP3A4 inhibitor (itraconazole) or inducer (rifampicin) on the pharmacokinetics of the epidermal growth factor receptor‐tyrosine kinase inhibitor osimertinib,



Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.

Inhibition of the cytochrome P450IIIA by ketoconazole and itraconazole may explain the observed pharmacokinetic interaction and prescription of midazolam for patients receiving ketocon Razolam and itRaconazoles should be avoided.

Triazolam in cirrhosis: Pharmacokinetics and pharmacodynamics

The findings show that there were no significant differences between the patients with cirrhosis and the control subjects in any of the pharmacokinetic parameters, and the ratio of effect area under the curve to concentration area underThe curve, a measure of sensitivity, did not differ significantly.

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences.

Ketoconazole alters the metabolism of terfenadine in normal men and women and results in the accumulation of unmetabolized parent drug, which is associated with significant prolongation of the corrected QT interval and should be avoided.

Measurement of Recovery from Outpatient General Anaesthesia with a Simple Ocular Test

Recovery rates after methohexitone and propanidid were similar and rapid enough to confirm their choice for intravenous induction of anaesthesia in outpatients, but delayed recovery after thiopentone showed that this agent is best avoided in these circumstances.

Pencil and paper tests--sensitivity to psychotropic drugs.

  • B. Stone
  • Psychology
    British journal of clinical pharmacology
  • 1984
Pencil and paper tests which measure various skills are useful for detecting drug effects, but letter cancellation, arithmetic and DSST appear to be most sensitive, although logic and symbol copying may be useful.

Triazolam hydroxylation in vitro: species differences and metabolic inhibition

    Oxidation of midazolam and triazolam by human liver cytochrome P 4501 I 1 A 4

    • Therapeutic drugs
    • 1991