Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis.

Abstract

Laquinimod is an orally active molecule that showed efficacy in clinical trials in multiple sclerosis. We studied its effects in the CNS, when administered by therapeutic regimen to mice inflicted with experimental autoimmune encephalomyelitis (EAE). Laquinimod reduced clinical and inflammatory manifestations and elevated the prevalence of T-regulatory… (More)
DOI: 10.1016/j.jneuroim.2012.06.005

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@article{Aharoni2012OralTW, title={Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis.}, author={Rina Aharoni and R. Ami Saada and Raya Eilam and Liat Hayardeny and M. N. Sela and Ruth Arnon}, journal={Journal of neuroimmunology}, year={2012}, volume={251 1-2}, pages={14-24} }