Oral transmucosal fentanyl citrate: overview of pharmacological and clinical characteristics.

@article{Mystakidou2006OralTF,
  title={Oral transmucosal fentanyl citrate: overview of pharmacological and clinical characteristics.},
  author={Kyriaki Mystakidou and Emmanuela Katsouda and Efi Parpa and Lambros Vlahos and Marinos L. Tsiatas},
  journal={Drug delivery},
  year={2006},
  volume={13 4},
  pages={269-76}
}
Oral transmucosal fentanyl citrate (OTFC; brand name Actiq, Cephalon, UT) is a new opioid formulation that incorporates fentanyl into a lozenge and allows drug delivery through the buccal mucosa. This kind of absorption avoids first-pass metabolism, yielding a bioavailability substantially greater than oral administration. OTFC has a rapid onset of action and a short duration of effect. These characteristics, which resemble the course of a typical breakthrough pain episode, resulted in making… CONTINUE READING
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