Oral thyroxine: variation in biologic action and tablet content.

@article{Sawin1984OralTV,
  title={Oral thyroxine: variation in biologic action and tablet content.},
  author={Clark T. Sawin and Martin I. Surks and Matthew S London and C. Ranganathan and P. R. Larsen},
  journal={Annals of internal medicine},
  year={1984},
  volume={100 5},
  pages={
          641-5
        }
}
Thirty-two patients with primary hypothyroidism were given oral thyroxine as Levothroid or Synthroid to see if the two preparations had similar effects. The serum thyroxine was used as an index of bioavailability and the serum thyrotrophin as an index of biologic activity. The serum thyroxine was lower in all 32 patients when taking Synthroid than when taking Levothroid. In 15 patients the serum thyroxine level fell low enough to raise the serum thyrotrophin; in all 15 the serum thyrotrophin… CONTINUE READING
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