Oral therapy with dipyridamole limits ischemia-reperfusion injury in humans.

@article{Riksen2005OralTW,
  title={Oral therapy with dipyridamole limits ischemia-reperfusion injury in humans.},
  author={Niels P. Riksen and Wim J. G. Oyen and Bart P C Ramakers and Petra van den Broek and Richard Engbersen and Otto C Boerman and P. G. F. M. Smits and Gerard A P J M Rongen},
  journal={Clinical pharmacology and therapeutics},
  year={2005},
  volume={78 1},
  pages={52-9}
}
BACKGROUND Adenosine receptor stimulation induces several effects that could limit ischemia-reperfusion injury. We hypothesize that treatment with the nucleoside uptake inhibitor dipyridamole increases endogenous adenosine and limits ischemia-reperfusion injury in humans. METHODS Ischemia-reperfusion injury was studied in forearm skeletal muscle by technetium Tc 99m-labeled annexin A5 scintigraphy. Ischemia-reperfusion injury was induced by unilateral forearm ischemic exercise. Immediately on… CONTINUE READING

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