Oral temazepam as a premedicant in elderly general surgical patients

  title={Oral temazepam as a premedicant in elderly general surgical patients},
  author={M. Salonen and Jussi H. Kanto and M. Hovi-Viander and Kerttu Irjala and Osmo Viinam{\"a}ki},
  journal={Acta Anaesthesiologica Scandinavica},
In elderly, general surgical patients, oral temazepam 20 mg given in a soft gelatin capsule proved to be a useful light premedicant when given before spinal anaesthesia. In comparison with placebo, it caused preoperative subjective sedation, prevented an increase in heart rate and decreased serum Cortisol, but not serum antidiuretic hormone levels. However, simple devices (linear analogue scale, Maddox wing test, critical flicker fusion apparatus) appeared to be quite ineffective in… 
3 Citations
Plasma and cerebrospinal fluid concentrations of temazepam following oral drug administration
Temazepam appeared to be an effective light pre-medicant in all of the subjects studied and a highly significant correlation existed between the unbound concentration of temazepAM in plasma and the concentration of drug present in CSF.
The relationship between clinical effect and concentrations of temazepam in plasma and cerebrospinal fluid
Because sedative and anxiolytic effects are poorly correlated, but the amnesic effect is well correlated with temazepam concentrations, different sites of action for these effects are suggested.
Preoperative Anxiety
The nature of preoperative anxiety appears to vary from patient to patient, and the natural course of the condition has not been well evaluated, so attempts to measure and relieve presurgical anxiety seem to be of clinical significance.


Temazepam as a premedicant in minor surgery
It is suggested that temazepam is a suitable drug for premedication for minor surgery.
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The advantages of the benzodiazpines as oral premedicants are clear anxiolytic and sedative effect, less clear amnesic action, convenient route of administration, and reduced frequency of side-effects before and after operation.
Preoperative medication for day-case surgery. A comparison between oxazepam and temazepam.
Two hours after surgery, no significant sedation was recorded with either drug, and simple psychomotor testing showed unimpaired performance, and patient acceptability was high with both oxazepam and temazepAM.
Sedation for upper gastro-intestinal endoscopy. A comparison of oral temazepam and i.v. diazepam.
The oral presentation, avoiding the pain of injection and the possible shorter duration of action, made oral temazepam preferable to i.v. diazepam, the endoscopists found.
Measurement of Recovery from Outpatient General Anaesthesia with a Simple Ocular Test
Recovery rates after methohexitone and propanidid were similar and rapid enough to confirm their choice for intravenous induction of anaesthesia in outpatients, but delayed recovery after thiopentone showed that this agent is best avoided in these circumstances.
Temazepam as premedication in day surgery
Sixty patients scheduled for day case surgery were allocated into two groups in a double‐blind study. One group received temazepam 20 mg or 30 mg orally 1 hour before surgery whilst the second group
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It was concluded that not only did diazepam differentially reduce anxiety levels in accordance with the degree of anxiety present, but that it also reduced to normal levels the excessive amount of thiopental sodium needed fort the induction of anxious patient.
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The available evidence seems to support the conclusion that only for methotrexate and antibacterial agents does knowledge of cerebrospinal fluid pharmacokinetics have direct therapeutic implications, while the mosaic of information available for other drugs does little more than provide a partially satisfactory picture.
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It is necessary to select patients suitable for palliative care on the basis of prior history and once they are able to provide informed consent for treatment of complex medical conditions.
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  • Medicine
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