Oral temazepam as a premedicant in elderly general surgical patients

@article{Salonen1986OralTA,
  title={Oral temazepam as a premedicant in elderly general surgical patients},
  author={M. Salonen and Jussi H. Kanto and M. Hovi-Viander and Kerttu Irjala and Osmo Viinam{\"a}ki},
  journal={Acta Anaesthesiologica Scandinavica},
  year={1986},
  volume={30}
}
In elderly, general surgical patients, oral temazepam 20 mg given in a soft gelatin capsule proved to be a useful light premedicant when given before spinal anaesthesia. In comparison with placebo, it caused preoperative subjective sedation, prevented an increase in heart rate and decreased serum Cortisol, but not serum antidiuretic hormone levels. However, simple devices (linear analogue scale, Maddox wing test, critical flicker fusion apparatus) appeared to be quite ineffective in… 
3 Citations
Plasma and cerebrospinal fluid concentrations of temazepam following oral drug administration
TLDR
Temazepam appeared to be an effective light pre-medicant in all of the subjects studied and a highly significant correlation existed between the unbound concentration of temazepAM in plasma and the concentration of drug present in CSF.
The relationship between clinical effect and concentrations of temazepam in plasma and cerebrospinal fluid
TLDR
Because sedative and anxiolytic effects are poorly correlated, but the amnesic effect is well correlated with temazepam concentrations, different sites of action for these effects are suggested.
Preoperative Anxiety
TLDR
The nature of preoperative anxiety appears to vary from patient to patient, and the natural course of the condition has not been well evaluated, so attempts to measure and relieve presurgical anxiety seem to be of clinical significance.

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