Oral sumatriptan and almotriptan--delimiting the MAOI effect.

  title={Oral sumatriptan and almotriptan--delimiting the MAOI effect.},
  author={Florian Oberhardt and Anthony W. Fox},
  volume={52 5},
OBJECTIVES/BACKGROUND (1) To investigate whether a parsimonious model for sumatriptan pharmacokinetics can apply to oral administration; (2) for a successful model, whether a monoamine oxidase A inhibitor (MAOI-A) perturbs it; and (3) whether such a model is generalizable to oral almotriptan. These goals respond to statements in US product labeling. METHODS Extension of a previous model for subcutaneous sumatriptan. Numerical solutions to 3 concurrent differential equations were found, with… CONTINUE READING