Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes.

@article{Schwartz2001OralSC,
  title={Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes.},
  author={Stephen M Schwartz and David R. Doody and E. Dawn Fitzgibbons and Sherianne Ricks and Peggy L. Porter and Chu Chen},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2001},
  volume={10 11},
  pages={1137-44}
}
Heavy alcohol consumption, particularly in combination with cigarette smoking, increases the risk of oral squamous cell carcinoma (OSCC). Alcohol dehydrogenase 3 (ADH3) converts ethanol to acetaldehyde, which is a suspected oral carcinogen. The ADH3*1 allele is associated with increased conversion of ethanol to acetaldehyde, but whether the risk of OSCC is increased among ADH3*1 carriers, or whether the risk of OSCC attributable to alcohol consumption is modified by ADH3 genotype is unclear… CONTINUE READING

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