Oral spirochetes: Pathogenic mechanisms in periodontal disease.

  title={Oral spirochetes: Pathogenic mechanisms in periodontal disease.},
  author={Leila Yousefi and Hamed Ebrahimzadeh Leylabadlo and Tala Pourlak and Hosein Eslami and Sepehr Taghizadeh and Khudaverdi Ganbarov and Mehdi Yousefi and Asghar Tanomand and Bahman Yousefi and Hossein Samadi Kafil},
  journal={Microbial pathogenesis},

Immune Responses Regulated by Key Periodontal Bacteria in Germ-Free Mice

The overall immunoregulation of monomicrobial stimuli to decipher the complexities of periodontitis was provided in this study and induced the strongest innate immune response in gingiva and mononuclear phagocytes changed most significantly.

The interplay between oral microbes and immune responses

How oral microbes communicate with hosts during the development of local and distant inflammation is reviewed to reveal future directions in this field and the potential targets of novel biological therapies for oral and systemic diseases.

Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review.

  • Ying WeiYaxin Deng Xing Tang
  • Medicine
    Journal of controlled release : official journal of the Controlled Release Society
  • 2021

Treatment challenges and delivery systems in immunomodulation and probiotic therapies for periodontitis

A critical review of the status of current treatment approaches to periodontitis is provided, with a focus on promising immunomodulation and probiotic therapies based on delivery of small molecules, peptides, proteins, DNA or RNA, and probiotics.

Biomaterials and Biological Parameters for Fixed-Prosthetic Implant-Supported Restorations: A Review Study

The aim of this overview was to focus on the nature of the disease itself, useful diagnostic criteria, common responsible bacteria, and the prosthetic effects of fixed restorations on the health of the periodontium since recognizing the parameters involved in the development of periodontal and PIDs will play a crucial role in preventing the progression and minimizing the complications of these diseases having a fixed prosthesis.

The Characteristics of Microbiome and Cytokines in Healthy Implants and Peri-Implantitis of the Same Individuals

There are more pathogenic bacteria and inflammatory cytokines inperi-implantitis sites, and biomarkers could facilitate the diagnosis of peri-IMplantitis.

Measurement of the Level of Nitric Oxide in Exhaled Air in Patients Using Acrylic Complete Dentures and with Oral Pathologies

The purpose of this study was to determine the impact of inflammation in the oral cavity (according to the material of dentures) on the level of nitric oxide in exhaled air.

Oral delivery of glutathione: antioxidant function, barriers and strategies

Approaches explored to developing an oral GSH delivery system that could provide protection against proteolytic degradation in the GI tract and enhance molecular absorption across the epithelial membrane are discussed.

Characteristics of oral microbiome of healthcare workers in different clinical scenarios: a cross-sectional analysis

The oral microbiome profile of healthcare workers in different clinical scenarios was described and it was demonstrated that community diversity, structure, and potential functions differed markedly among departments.



Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease.

It is demonstrated that HGFs do not show LPS tolerance and suggested that this characteristic of H GFs sustains the inflammatory response in the presence of virulence factors.

Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer's Disease

The aim of this review is to discuss the relevance of finding the keystone periodontal pathogen P. gingivalis in AD brains and its plausible contribution to the aetiological hypothesis of this dementing condition.

The Role of Spirochetes in Periodontal Disease

  • W. Loesche
  • Medicine, Biology
    Advances in dental research
  • 1988
The spirochetal accumulation in subgingival plaque appears to be a function of the clinical severity of periodontal disease, and the overgrowth of spirochetes can be clinically useful if simply interpreted as indicating the result of tissue damage.

Role of Porphyromonas gingivalis gingipains in multi-species biofilm formation

The present experimental model reveals interdependency between the gingipains of P. gingivalis and T. denticola, and may qualitatively and quantitatively affect composition of polymicrobial biofilms.

Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts.

It seems that it is indeed the initial early host-inflammatory and immune responses occurring during the development of gingivitis, and not specific bacteria or their so-called virulence factors, which determine whether periodontitis develops and progresses.

Inflammatory and immune pathways in the pathogenesis of periodontal disease.

Current knowledge of the host response in periodontitis is delineated to delineate the role of innate immunity, the failure of acute inflammation to resolve (thus becoming chronic), the cytokine pathways that regulate the activation of acquired immunity and the cells and products of the immune system are considered.

The periodontal war: microbes and immunity

Maintenance of periodontal health or transition to a periodontal lesion reflects the continuous and ongoing battle between the vast microbial ecology in the oral cavity and the array of resident and

Microbial flora in oral diseases.

An overview of the altered flora in diseased states is given in an attempt to give an overview of how these microorganisms may lead to systemic diseases like diabetes or atherosclerosis.

Role of oral microbiome on oral cancers, a review.

Invasion of Oral and Aortic Tissues by Oral Spirochete Treponema denticola in ApoE−/− Mice Causally Links Periodontal Disease and Atherosclerosis

A causal link for active oral T. denticola periodontal infection and vascular atherosclerosis in vivo in hyperlipidemic ApoE−/− mice is confirmed.