Oral spirochetes: Pathogenic mechanisms in periodontal disease.

  title={Oral spirochetes: Pathogenic mechanisms in periodontal disease.},
  author={Leila Yousefi and Hamed Ebrahimzadeh Leylabadlo and Tala Pourlak and Hosein Eslami and Sepehr Taghizadeh and Khudaverdi Ganbarov and Mehdi Yousefi and Asghar Tanomand and Bahman Yousefi and Hossein Samadi Kafil},
  journal={Microbial pathogenesis},
Periodontitis is an infectious inflammatory disease resulting from infection of biofilm forming bacteria. Several bacterial factors regulate inflammatory response and cause to tissue damage and loss of connection between gingival and tooth. Since bacterial virulence factors and also host immune responses have role, understanding of periodontal disease is complex, in overall we can say that in this disease epithelium is deleted by bacteria. Oral spirochetes are related to periodontitis, among… 
5 Citations
Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review.
  • Ying Wei, Yaxin Deng, +10 authors Xing Tang
  • Medicine
    Journal of controlled release : official journal of the Controlled Release Society
  • 2021
This review highlights applications of LDDS with different properties in the treatment of periodontitis with or without systemic diseases, in order to reveal existing challenges and future research directions.
Treatment challenges and delivery systems in immunomodulation and probiotic therapies for periodontitis
A critical review of the status of current treatment approaches to periodontitis is provided, with a focus on promising immunomodulation and probiotic therapies based on delivery of small molecules, peptides, proteins, DNA or RNA, and probiotics.
The critical role of Faecalibacterium prausnitzii in human health: An overview.
This review aims to consider literature from various library databases and electronic searches which serve as an overview of different features of F. prausnitzii including metabolites, anti-inflammatory action, and correlation of dysbiosis of this bacterium with various complications in human.
Measurement of the Level of Nitric Oxide in Exhaled Air in Patients Using Acrylic Complete Dentures and with Oral Pathologies
The measurement of nitric oxide (NO) in exhaled air is used in diagnostics and monitoring of the pathologies in the respiratory system but also in the oral cavity. Researchers have shown a huge
Biomaterials and Biological Parameters for Fixed-Prosthetic Implant-Supported Restorations: A Review Study
Because of the increasing use of dental implants, dental practitioners should understand the treatment and nature of peri-implant diseases (PIDs). This disease is a serious problem of dentistry,


Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease.
It is demonstrated that HGFs do not show LPS tolerance and suggested that this characteristic of H GFs sustains the inflammatory response in the presence of virulence factors.
Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer's Disease
The aim of this review is to discuss the relevance of finding the keystone periodontal pathogen P. gingivalis in AD brains and its plausible contribution to the aetiological hypothesis of this dementing condition.
The Role of Spirochetes in Periodontal Disease
  • W. Loesche
  • Biology, Medicine
    Advances in dental research
  • 1988
The spirochetal accumulation in subgingival plaque appears to be a function of the clinical severity of periodontal disease, and the overgrowth of spirochetes can be clinically useful if simply interpreted as indicating the result of tissue damage.
Role of Porphyromonas gingivalis gingipains in multi-species biofilm formation
The present experimental model reveals interdependency between the gingipains of P. gingivalis and T. denticola, and may qualitatively and quantitatively affect composition of polymicrobial biofilms.
Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts.
It seems that it is indeed the initial early host-inflammatory and immune responses occurring during the development of gingivitis, and not specific bacteria or their so-called virulence factors, which determine whether periodontitis develops and progresses.
Inflammatory and immune pathways in the pathogenesis of periodontal disease.
Current knowledge of the host response in periodontitis is delineated to delineate the role of innate immunity, the failure of acute inflammation to resolve (thus becoming chronic), the cytokine pathways that regulate the activation of acquired immunity and the cells and products of the immune system are considered.
The periodontal war: microbes and immunity
Maintenance of periodontal health or transition to a periodontal lesion reflects the continuous and ongoing battle between the vast microbial ecology in the oral cavity and the array of resident and
Microbial flora in oral diseases.
An overview of the altered flora in diseased states is given in an attempt to give an overview of how these microorganisms may lead to systemic diseases like diabetes or atherosclerosis.
Role of oral microbiome on oral cancers, a review.
The association between the development of oral cancer in potentially malignant oral lesions with chronic periodontitis, chronic Porphyromonas gingivalis, Fusobacterium nucleatum, candida, other microbes and described mechanisms which may be involved in these carcinoma are discussed.
Invasion of Oral and Aortic Tissues by Oral Spirochete Treponema denticola in ApoE−/− Mice Causally Links Periodontal Disease and Atherosclerosis
A causal link for active oral T. denticola periodontal infection and vascular atherosclerosis in vivo in hyperlipidemic ApoE−/− mice is confirmed.