Oral sex is associated with reduced incidence of recurrent miscarriage.

  title={Oral sex is associated with reduced incidence of recurrent miscarriage.},
  author={Tess Meuleman and N Baden and Geert W. Haasnoot and Marise M Wagner and Olaf M. Dekkers and Saskia le Cessie and Charles Picavet and Jan M M van Lith and Frans H. J. Claas and Kitty W. M. Bloemenkamp},
  journal={Journal of reproductive immunology},
A possible way of immunomodulation of the maternal immune system before pregnancy would be exposure to paternal antigens via seminal fluid to oral mucosa. We hypothesized that women with recurrent miscarriage have had less oral sex compared to women with uneventful pregnancy. In a matched case control study, 97 women with at least three unexplained consecutive miscarriages prior to the 20th week of gestation with the same partner were included. Cases were younger than 36 years at time of the… 
4 Citations
Regulatory T Cells in Pregnancy: It Is Not All About FoxP3
There appears to be great diversity within the Treg population during pregnancy, both at the maternal-fetal interface as in the peripheral blood, which suggests that distinct Treg subsets play a role at different time points of gestation and that their role in maintaining healthy pregnancy is crucial.
Oral tolerance and the materno-fetal relationship.
  • D. Clark
  • Medicine
    Journal of reproductive immunology
  • 2019
Issues relating to assessing the applicability of oral exposure to seminal plasma antigens in recurrent miscarriage are discussed and such tolerance could represent an unappreciated confounder in immunotherapy trials.


Sexual behavior and recurrent spontaneous abortion
  • R. Mattar, R.V. Pereira Soares, S. Daher
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2005
Whether sexual behavior influences the occurrence of RSA is investigated and number of sex partners use of condoms oral sex practice and exposure of the female oral mucosa to semen is investigated.
Correlation between oral sex and a low incidence of preeclampsia: a role for soluble HLA in seminal fluid?
The present study shows that oral sex and swallowing sperm is correlated with a diminished occurrence of preeclampsia which fits in the existing idea that a paternal factor is involved in the occurrence of peculiarity of preeClampsia.
Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia.
Findings indicate that paternal antigen exposure via the vaginal mucosa may facilitate immune tolerance to paternal HLA and advise nulliparous women to decrease their use of barrier contraceptive methods and to increase vaginal sexual intercourse prior to conceiving to reduce their risk of preeclampsia.
An Epidemiologic Study of Contraception and Preeclam psia
The results of this study were supportive of the hypothesis that birth control methods that prevent sperm exposure may play a role in the etiology of preeclampsia.
Epidemiology of Recurrent Spontaneous Abortion
  • C. Coulam
  • Medicine
    American journal of reproductive immunology
  • 1991
Data indicate that no difference in the prevalence of etiologies of RSA exist when couples with two or more abortions are compared with three or more and a comorbidity between RSA and other types of reproductive failure exists.
Duration of sexual relationship and its effect on preeclampsia and small for gestational age perinatal outcome.
Compared to uncomplicated pregnancies, short duration of sexual relationship is more common in women who develop preeclampsia and women with abnormal uterine artery Doppler waveforms who deliver an SGA baby.
New insights into mechanisms behind miscarriage
Recent experimental evidence has led to the concept that the decidualized endometrium acts as biosensor of embryo quality, which if disrupted, may lead to implantation of embryos destined to miscarry.
Soluble HLA levels in early pregnancy after in vitro fertilization.
Soluble HLA (sHLA) molecules increase during episodes of allograft rejection and are discussed as candidates to modulate immune responses and sHLA-DR levels increased during intact pregnancy but decreased in the group of early abortion.
Prevalence and correlates of heterosexual anal and oral sex in adolescents and adults in the United States.
It would be beneficial to track the prevalence of heterosexual anal and oral sex and associated condom use on a more frequent basis.
Recurrent miscarriage and thrombophilia: an update.
The cause of recurrent miscarriage is multifactorial and appropriate treatment continues to be a challenge and Laboratory tests need to be standardized and well designed multicentre research trials are essential to expand on the current knowledge base with the aim to produce strong evidence-based medicine.