Oral self-administration of triazolam, diazepam and ethanol in the baboon: drug reinforcement and benzodiazepine physical dependence

@article{Ator1992OralSO,
  title={Oral self-administration of triazolam, diazepam and ethanol in the baboon: drug reinforcement and benzodiazepine physical dependence},
  author={Nancy A. Ator and Roland R. Griffiths},
  journal={Psychopharmacology},
  year={1992},
  volume={108},
  pages={301-312}
}
Reinforcing and physical dependence-producing effects of oral diazepam and triazolam (0.01–1.28 mg/ml) were studied in four non-water-deprived baboons in daily 2-3-h sessions. Drinking initially was food-induced, but subsequently it was maintained for>year without the inducing procedures; drug intake>10 mg/kg per session was attained. Triazolam and diazepam reinforcement (compared to vehicle) was concluded for only one baboon for each drug under a single-spout procedure and for two baboons for… CONTINUE READING