Oral rehydration for viral gastroenteritis in adults: a randomized, controlled trial of 3 solutions.

  title={Oral rehydration for viral gastroenteritis in adults: a randomized, controlled trial of 3 solutions.},
  author={S. S. Rao and Robert W. Summers and G R S Rao and S. Ramana and Uma P Devi and Bridget M. Zimmerman and B. Pratap},
  journal={JPEN. Journal of parenteral and enteral nutrition},
  volume={30 5},
BACKGROUND Pedialyte and Gatorade are advocated for the treatment of dehydration in viral gastroenteritis, but there is limited evidence to support their use. We examine the efficacy, safety, and palatability of Pedialyte, Gatorade, and a New Oral Rehydration Solution (N-ORS). This was a randomized double-blind trial conducted in an inpatient, community hospital. Seventy-five consecutive adult patients (male, 42; female, 33) admitted with viral gastroenteritis were randomized to receive… 

Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis: A Randomized Clinical Trial.

Initial oral hydration with dilute apple juice followed by their preferred fluids, compared with electrolyte maintenance solution, resulted in fewer treatment failures and in many high-income countries, the use of dilute Apple juice and preferred fluids as desired may be an appropriate alternative to electrolye maintenance fluids in children with mild gastroenteritis and minimal dehydration.

Principles and Practice of Oral Rehydration

Oral rehydration solution remains the anchor of acute watery diarrhea and dehydration management worldwide and the current standard solution is the mainstay of treatment for nearly all situations.

Cost-effectiveness of preferred fluids versus electrolytes in pediatric gastroenteritis.

Apple juice/preferred fluids strategy was dominant over electrolytes in the treatment of children with minimal dehydration secondary to acute gastroenteritis as this option yielded fewer treatment failures and a lower societal cost.

Osmolality of Commercially Available Oral Rehydration Solutions: Impact of Brand, Storage Time, and Temperature

This investigation demonstrates that many commercially available pre-mixed ORS products do not currently adhere to the WHO recommended osmolality guidelines and, due to the presence of particular sugars and possibly other ingredients, the shelf-life stability of oSMolality for certain ORS Products may be questioned.

Efficacy of Glucose or Amino Acid–Based Commercial Beverages in Meeting Oral Rehydration Therapy Goals After Acute Hypertonic and Isotonic Dehydration

The results of this study demonstrate superior rehydration when using AA compared with SP for both hypertonic and isotonic dehydration.

Palatability assessment of an oral recuperation fluid in healthy dogs during the perioperative period.

A commercially manufactured veterinary ORF was found to be palatable, as determined by acceptance and preference testing, in healthy dogs during the preoperative and postoperative phases of routine sterilization.

Viral Gastroenteritis in the Adult Population

  • M. Krenzer
  • Medicine
    Critical Care Nursing Clinics of North America
  • 2012

Diarrhoea in adults (acute).

This systematic review presents information relating to the effectiveness and safety of the following interventions: antibiotics, antimotility agents, antisecretory agents, bismuth subsalicylate, diet, intravenous reHydration, nasogastric tube rehydration, oral rehydrated solutions, vitamin A supplementation, and zinc supplementation.

Clinical care of two patients with Ebola virus disease in the United States.

There was a concomitant decline in the amount of virus detected in plasma as the patients' condition improved clinically, and aggressive supportive measures of hydration and electrolyte correction were undertaken.

Risk of Norovirus Gastroenteritis from Consumption of Vegetables Irrigated with Highly Treated Municipal Wastewater—Evaluation of Methods to Estimate Sewage Quality

  • S. Barker
  • Medicine
    Risk analysis : an official publication of the Society for Risk Analysis
  • 2014
Quantitative microbial risk assessment was used to assess the risk of norovirus gastroenteritis associated with consumption of raw vegetables irrigated with highly treated municipal wastewater, using Melbourne, Australia as an example, and suggests that current wastewater reuse behaviors in Melbourne are unlikely to cause norov virus risks in excess of the annual DALY health target.



Use of a single solution for oral rehydration and maintenance therapy of infants with diarrhea and mild to moderate dehydration.

The two maintenance oral electrolyte solutions most commonly used in the United States are effective as rehydration solutions for infants with mild to moderate dehydration and might gain additional acceptance by practicing pediatricians and family physicians.

Clinical trial of glucose-oral rehydration solution (ORS), rice dextrin-ORS, and rice flour-ORS for the management of children with acute diarrhea and mild or moderate dehydration.

It is concluded that the three solutions had similar efficacy for children with acute, watery diarrhea and mild or moderate dehydration.

Safety and effectiveness of homemade and reconstituted packet cereal-based oral rehydration solutions: a randomized clinical trial.

CBORS do not offer a clinically significant advantage over glucose-based ORS, but it is not the safest alternative for regular clinical use.

Sodium content of oral rehydration solutions: a reappraisal.

In controlled clinical trials, oral rehydration solutions with 50-60 mmol/1 sodium have proven safe, and performance was compatible with WHO-ORS, and the solution proved effective for both reHydration and correction of acidosis.

Validity and reliability of clinical signs in the diagnosis of dehydration in children.

Conventionally used clinical signs of dehydration are valid and reliable; however, individual findings lack sensitivity and should be based on the presence of at least three clinical findings.

The Role of Oral Rehydration Solutions in the Children of Europe: Continuing Controversies

The role of oral rehydration solutions in the children of Europe‐ Continuing controversies is investigated to assess the need for further studies on the basis of available literature and anecdotal evidence.

Increasing prevalence of recurrent otitis media among children in the United States.

There has been a significant increase in the prevalence of recurrent otitis media among children in the United States, particularly in infants, and the increased prevalence was associated with an increase with the use of child care and a higher prevalence of allergic conditions among children.

Intestinal Electrolyte Transport and Diarrheal Disease

Enteric organisms cause diarrhea in several ways, some of which are noninvasive but secrete toxins that interact with intestinal epithelial cells to stimulate fluid secretion (e.g., cholera); others invade and destroy intestinal epithelium cells, thereby altering fluid transport.

Effects of carbohydrate type and concentration and solution osmolality on water absorption.

It is suggested that solutions with multiple substrates produce greater water absorption at a given osmolality than those with one, and several different solute absorption mechanisms yielding greaterWater absorption than solutions with only one substrate.