Oral quinine for the treatment of uncomplicated malaria

@article{Reyburn2009OralQF,
  title={Oral quinine for the treatment of uncomplicated malaria},
  author={Hugh Reyburn and George Mtove and Ilse C. E. Hendriksen and Lorenz von Seidlein},
  journal={BMJ : British Medical Journal},
  year={2009},
  volume={339}
}
Is ineffective in outpatients and should be used only in rare cases 
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References

SHOWING 1-10 OF 18 REFERENCES
In vitro activity of chloroquine, quinine, mefloquine and halofantrine against Gabonese isolates of Plasmodium falciparum
TLDR
To determine the in vitro activity of antimalarial drugs against isolates of Plasmodium falciparum in Gabon, a large number of drugs were found to be effective against these isolates. Expand
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
TLDR
Artesunate should become the treatment of choice for severe falciparum malaria in adults because it is more rapidly acting than intravenous quinine in terms of parasite clearance and is simpler to administer. Expand
Malaria drug shortages in Kenya: a major failure to provide access to effective treatment.
TLDR
Two years after artemether-lumefathrine was introduced for the management of uncomplicated malaria in Kenya, a cross-sectional survey to investigate AL availability found one of four of the surveyed facilities had none of the four AL weight-specific treatment packs in stock. Expand
The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs
TLDR
Evidence is provided of the presence, in Ghana, of P. falciparum isolates that are highly resistant to chloroquine but generally sensitive to most of the other antimalarial drugs commonly used in the country. Expand
Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial
TLDR
The effectiveness of a seven day course of quinine for the treatment of uncomplicated malaria in Ugandan children was significantly lower than that of artemether-lumefantrine, and these findings question the advisability of the recommendation forQuinine therapy for uncomplication malaria in Africa. Expand
Artesunate combinations for treatment of malaria: meta-analysis
TLDR
The addition of 3 days of artesunate to standard antimalarial treatments substantially reduce treatment failure, recrudescence, and gametocyte carriage. Expand
Artemether-lumefantrine (six-dose regimen) for treating uncomplicated falciparum malaria.
TLDR
The six-dose regimen of artemether-lumefantrine appears more effective than antimalarial regimens not containing artemisinin derivatives. Expand
Artemether-lumefantrine (four-dose regimen) for treating uncomplicated falciparum malaria.
TLDR
The four- dose regimen of artemether-lumefantrine seems to be less effective than regimens against which it has been tested, and the six-dose regimen is superior to four- overdose regimen. Expand
In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda.
TLDR
Worrying is the positive correlation between the IC(50) of dihydroartemisinin and the other drugs, more particularly with CQ, suggesting an increased tolerance of the parasites to all drugs. Expand
Guidelines for the treatment of malaria
The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning theExpand
...
1
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