Oral quinine for the treatment of uncomplicated malaria

  title={Oral quinine for the treatment of uncomplicated malaria},
  author={Hugh Reyburn and George Mtove and Ilse C. E. Hendriksen and Lorenz von Seidlein},
  journal={BMJ : British Medical Journal},
Is ineffective in outpatients and should be used only in rare cases 

Efficacy of Quinine, Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine as Rescue Treatment for Uncomplicated Malaria in Ugandan Children

Recurrent infections observed after the administration of an ACT can be successfully treated with an alternative ACT rather than with quinine, as shown in a nested, randomized, open label, three-arm clinical trial of rescue therapy in children with recurrent malaria infection.

Artemisia annua, Artemisinin, ACTs and Malaria Control in Africa: The Interplay of Tradition, Science and Public Policy

The key ingredient in the leading treatment for malaria in Africa artemisinin comes not from hightech research, but is an extract of an ancient medicinal plant, Artemisia annua, commonly known as

Discovery of anti-malarial agents through application of in silico studies.

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Novel quinine, lupinine, and anabasine derivatives containing dithiophosphinate groups

A three-component, atom-economic reaction between natural quinine, lupinine, or anabasine, secondary phosphines, and elemental sulfur occurs under mild conditions to yield previously unknown

Potential Anti-Mycobacterium tuberculosis Activity of Plant Secondary Metabolites: Insight with Molecular Docking Interactions

In silico studies can reveal the inhibitory potential of plant-derived secondary metabolites against Mycobacterium at the very early stage of infection, and computational approaches based on different algorithms could play a significant role in screening plant metabolites against disease virulence of tuberculosis for drug designing.

Molecular Malaria Epidemiology: Mapping and Burden Estimates for the Democratic Republic of the Congo, 2007

New high-throughput molecular testing offers a new, generalizable, and efficient approach to characterizing malaria endemicity in underserved countries and is associated with under-5 mortality in the DRC.

Pharmaceutical activities of Phytochemicals in Murraya spp.-a review

The leaf, flower and fruit extracts of Murraya exotica have been reported to show anti-bacterial effect and the main categories of phytochemicals present in Murraya spp.

Biowaiver monographs for immediate-release solid oral dosage forms: quinine sulfate.

The biowaiver approach permits evaluation of bioequivalence (BE) using a set of laboratory tests, obviating the need for expensive and time-consuming pharmacokinetic BE studies provided that both the


The study reveals the antiproliferative nature of C. retusa, with Jurkat being the most sensitive cell line, and the antioxidant potential of this plant could be due in part, to its total phenol content.



In vitro activity of chloroquine, quinine, mefloquine and halofantrine against Gabonese isolates of Plasmodium falciparum

To determine the in vitro activity of antimalarial drugs against isolates of Plasmodium falciparum in Gabon, a large number of drugs were found to be effective against these isolates.

Malaria drug shortages in Kenya: a major failure to provide access to effective treatment.

Two years after artemether-lumefathrine was introduced for the management of uncomplicated malaria in Kenya, a cross-sectional survey to investigate AL availability found one of four of the surveyed facilities had none of the four AL weight-specific treatment packs in stock.

The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs

Evidence is provided of the presence, in Ghana, of P. falciparum isolates that are highly resistant to chloroquine but generally sensitive to most of the other antimalarial drugs commonly used in the country.

Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial

The effectiveness of a seven day course of quinine for the treatment of uncomplicated malaria in Ugandan children was significantly lower than that of artemether-lumefantrine, and these findings question the advisability of the recommendation forQuinine therapy for uncomplication malaria in Africa.

Artemether-lumefantrine (six-dose regimen) for treating uncomplicated falciparum malaria.

The six-dose regimen of artemether-lumefantrine appears more effective than antimalarial regimens not containing artemisinin derivatives.

Artemether-lumefantrine (four-dose regimen) for treating uncomplicated falciparum malaria.

The four- dose regimen of artemether-lumefantrine seems to be less effective than regimens against which it has been tested, and the six-dose regimen is superior to four- overdose regimen.

Guidelines for the treatment of malaria

The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the