Oral pilocarpine for symptomatic relief of keratoconjunctivitis sicca in patients with Sjögren's syndrome. The MGI PHARMA Sjögren's Syndrome Study Group.

  title={Oral pilocarpine for symptomatic relief of keratoconjunctivitis sicca in patients with Sj{\"o}gren's syndrome. The MGI PHARMA Sj{\"o}gren's Syndrome Study Group.},
  author={J D Nelson and Mitchell H. Friedlaender and R. Patrick Yeatts and Richard W. Yee and M McDermott and Stephen E. Orlin and Susan C. Gallagher and Radheshyam Shrotriya},
  journal={Advances in experimental medicine and biology},
Sjogren’s syndrome (SS) was first described by Henrik Sjogren, who documented association of rheumatoid arthritis and systemic immunopathy characterized by symptoms of dryness, especially KCS and xerostomia. 
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The aim of this article is to describe the main symptoms, the currently used different diagnostic criteria and the available treatment for Sjögren's syndrome. Expand
Diagnóstico e tratamento da síndrome de Sjögren
The aim of this article is to describe the main symptoms, the currently used different diagnostic criteria and the available treatment for Sjogren's syndrome. Expand
Dry Eye Syndrome
KCS is a multifactorial disorder due to inflammation of the ocular surface and lacrimal gland, neurotrophic deficiency and meibomian gland dysfunction, which has led to the development of new and more effective medications. Expand
The treatment of Sjögren's syndrome patients with Pilocarpine-tablets
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Data from human and animal models suggest that regular use of pilocarpine may not only improve patient quality of life but potentially prevent complications as well. Expand
Pharmacotherapy of Xerostomia in Primary Sjögren's Syndrome
We reviewed the current literature concerning the treatment of dry mouth in patients with primary Sjögren's syndrome (SJS). Computerized MEDLINE search engines were used with the terms Sjögren,Expand
A Scleroderma Patient Complaining of Dry and Gritty Sensation of the Eyes
The aim of management of dry eyes is to provide symptomatic relief, reduce ocular surface inflammation, and prevent complications. Expand
Oral pilocarpine for the treatment of keratoconjunctivitis sicca with central corneal irregularity.
Oral pilocarpine (Salagen) was prescribed, which improved salivation, lacrimation, and keratoconjunctivitis sicca and the patient was able to tolerate rigid gas-permeable contact lenses to achieve 20/20 visual acuity in both eyes and regain binocular vision. Expand
Sjögren's syndrome comes of age.
A two-stage model of SS pathogenesis is proposed in which the initial process seems to be increased epithelial cell apoptosis leading to autoantibody production and subsequent salivary gland lymphocytic infiltration. Expand
Use of muscarinic agonists in the treatment of Sjögren's syndrome.
Two muscarinic agonists (pilocarpine and cevimeline) have recently been approved for the treatment of symptoms of xerostomia in Sjögren's syndrome, highlighting the importance of neuroendocrine mechanisms in SS. Expand
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SummaryThere is increasing awareness that sicca syndrome can lead to ocular, oral and systemic complications. However, a wide variety of pathogenetic processes may lead to the same end result ofExpand
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The clinical and laboratory features of patients referred for evaluation of sicca symptoms are reviewed, and the need for care in choosing the site for minor salivary gland biopsy is emphasized, and histologic features that aid in the evaluation of these biopsy specimens are described. Expand
Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer.
Pilocarpine improved saliva production and relieved symptoms of xerostomia after irradiation for cancer of the head and neck, with minor side effects that were predominantly limited to sweating. Expand
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It is concluded that in these studies pilocarpine produced clinically significant benefits with acceptable side effects and risks for the treatment of symptomatic postradiation xerostomia. Expand
National Sjogren’s Syndrome Association
Dear friends, there are differences all around us. We think differently. We act differently. Different things are important to us. We even look different. We can compare our differences all day andExpand
A multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients.
It is concluded that pilocarpine produces clinically significant benefits for the symptomatic treatment of postradiation xerostomia and for saliva production in patients with head and neck cancer. Expand
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