Oral pilocarpine for symptomatic relief of keratoconjunctivitis sicca in patients with Sjögren's syndrome. The MGI PHARMA Sjögren's Syndrome Study Group.

@article{Nelson1998OralPF,
  title={Oral pilocarpine for symptomatic relief of keratoconjunctivitis sicca in patients with Sj{\"o}gren's syndrome. The MGI PHARMA Sj{\"o}gren's Syndrome Study Group.},
  author={J D Nelson and Mitchell H. Friedlaender and R. Patrick Yeatts and Richard W. Yee and M McDermott and Stephen E. Orlin and Susan C. Gallagher and Radheshyam Shrotriya},
  journal={Advances in experimental medicine and biology},
  year={1998},
  volume={438},
  pages={
          979-83
        }
}
Sjogren’s syndrome (SS) was first described by Henrik Sjogren, who documented association of rheumatoid arthritis and systemic immunopathy characterized by symptoms of dryness, especially KCS and xerostomia. 
[Sjögren's syndrome: diagnosis and treatment].
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The aim of this article is to describe the main symptoms, the currently used different diagnostic criteria and the available treatment for Sjögren's syndrome. Expand
Diagnóstico e tratamento da síndrome de Sjögren
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The aim of this article is to describe the main symptoms, the currently used different diagnostic criteria and the available treatment for Sjogren's syndrome. Expand
Dry Eye Syndrome
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KCS is a multifactorial disorder due to inflammation of the ocular surface and lacrimal gland, neurotrophic deficiency and meibomian gland dysfunction, which has led to the development of new and more effective medications. Expand
The treatment of Sjögren's syndrome patients with Pilocarpine-tablets
  • F. Vivino
  • Medicine
  • Scandinavian journal of rheumatology. Supplement
  • 2001
TLDR
Data from human and animal models suggest that regular use of pilocarpine may not only improve patient quality of life but potentially prevent complications as well. Expand
Pharmacotherapy of Xerostomia in Primary Sjögren's Syndrome
We reviewed the current literature concerning the treatment of dry mouth in patients with primary Sjögren's syndrome (SJS). Computerized MEDLINE search engines were used with the terms Sjögren,Expand
A Scleroderma Patient Complaining of Dry and Gritty Sensation of the Eyes
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The aim of management of dry eyes is to provide symptomatic relief, reduce ocular surface inflammation, and prevent complications. Expand
Oral pilocarpine for the treatment of keratoconjunctivitis sicca with central corneal irregularity.
TLDR
Oral pilocarpine (Salagen) was prescribed, which improved salivation, lacrimation, and keratoconjunctivitis sicca and the patient was able to tolerate rigid gas-permeable contact lenses to achieve 20/20 visual acuity in both eyes and regain binocular vision. Expand
Sjögren's syndrome comes of age.
TLDR
A two-stage model of SS pathogenesis is proposed in which the initial process seems to be increased epithelial cell apoptosis leading to autoantibody production and subsequent salivary gland lymphocytic infiltration. Expand
Use of muscarinic agonists in the treatment of Sjögren's syndrome.
TLDR
Two muscarinic agonists (pilocarpine and cevimeline) have recently been approved for the treatment of symptoms of xerostomia in Sjögren's syndrome, highlighting the importance of neuroendocrine mechanisms in SS. Expand
Treatment of dry eye disease by the non-ophthalmologist.
  • G. Foulks
  • Medicine
  • Rheumatic diseases clinics of North America
  • 2008
TLDR
The understanding of dry eye disease in both its clinical expression and underlying etiopathology has expanded over the past 10 years with implications for management and therapy. Expand
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