Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer.

@article{Johnson1993OralPF,
  title={Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer.},
  author={Jonas T. Johnson and Gerald A. Ferretti and W J Nethery and I H Valdez and Philip C. Fox and Dr Eric Ng and Charles C Muscoplat and Susan C Gallagher},
  journal={The New England journal of medicine},
  year={1993},
  volume={329 6},
  pages={390-5}
}
BACKGROUND AND METHODS We evaluated pilocarpine hydrochloride for the treatment of radiation-induced xerostomia, a common complication of irradiation of the head and neck. A prospective, randomized, double-blind, placebo-controlled trial was undertaken to test the safety and efficacy of pilocarpine, particularly in reversing the decrease in the production of saliva and other manifestations of xerostomia. Patients received either placebo or pilocarpine (5 mg or 10 mg orally three times a day… CONTINUE READING

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