Oral physostigmine and impaired memory in adults with brain injury.

  title={Oral physostigmine and impaired memory in adults with brain injury.},
  author={Diana D. Cardenas and Adam McLean and L Farrell-Roberts and Lisa N. Baker and Marian Brooke and Jodie Haselkorn},
  journal={Brain injury},
  volume={8 7},
The purpose of this study was to examine the effects of physostigmine, a cholinergic agonist, on memory loss after traumatic brain injury (TBI), as compared to placebo or scopolamine, a cholinergic antagonist, using a double-blind, placebo-controlled design. Each subject received each active drug and placebo. Neuropsychological measures (Wechsler Memory Scale I and II, Selective Reminding Test, Trail-Making Test, Parts A and B, Digit Symbol, and Memory Questionnaire) and measures of clinical… CONTINUE READING

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