Oral oseltamivir in human experimental influenza B infection.

  title={Oral oseltamivir in human experimental influenza B infection.},
  author={Frederick G. Hayden and Lance Jennings and R. M. Reecy Robson and Gilbert M. Schiff and Helen Jackson and Binay Rana and Grant B. McClelland and David Ipe and Noel K. Roberts and Penelope Ward},
  journal={Antiviral therapy},
  volume={5 3},
Oseltamivir is the prodrug of Ro64-0802 (GS4071), a potent and selective inhibitor of influenza A and B virus neuraminidases. Three randomized, double-blind, placebo-controlled, parallel-group studies evaluated oral oseltamivir for early treatment (75 or 150 mg twice daily for 5 days) or prevention (75 mg once or twice daily for 7 days) of experimental influenza B virus infection in healthy susceptible adults. Treatment study A (n=60) demonstrated similar trends to treatment study B (n=117), in… CONTINUE READING


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