Oral nicotinamide reduces transepidermal water loss: a randomized controlled trial

  title={Oral nicotinamide reduces transepidermal water loss: a randomized controlled trial},
  author={Andrew C Chen and A.J. Martin and R.A. Dalziell and Gary M. Halliday and Diona L Damian},
  journal={British Journal of Dermatology},
DEAR EDITOR, Transepidermal water loss (TEWL) is a measure of barrier function which correlates with stratum corneum disruption and clinical severity in atopic dermatitis. Emollients may increase or decrease TEWL, but may not fully restore barrier function. Nicotinamide (an amide form of vitamin B3) has central roles in energy metabolism and DNA repair. We recently found that nicotinamide reduced new nonmelanoma skin cancers and actinic keratoses in patients at high risk. Nicotinamide also… 


Niacinamide improves skin barrier function and therefor can be effective in treating xerosis, atopic dermatitis and rosacea and can be an important adjunctive therapeutic in conditions such as pemphigus vulgaris and psoriasis.

Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety

Nicotinamide prevents ultraviolet radiation from reducing ATP levels and inhibiting glycolysis, thus preventing the UV radiation‐induced energy crisis and enhances DNA repair and reduces UV‐induced suppression of immunity.

Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention

Oral NAM administration reduces the level of UV-mediated immunosuppression and lowers the rate of non-melanoma skin cancers in high-risk patients, suggesting NAM replenishment strategy may be a promising approach for skin cancer chemoprevention.

Nicotinamide: Mechanism of action and indications in dermatology

Vitamin B3 is a water‐soluble vitamin that is not stored in the body and the main source of vitamin in diet is in the form of nicotinamide, nicotinic acid, and tryptophan.

Peran Stres Oksidatif dan Antioksidan pada Dermatitis Atopik

Dermatitis atopik (DA) adalah kelainan kulit dengan gejala pruritus kronis. Etiopatogenesis penyakit ini kompleks dan multifactorial dengan gabungan aspek genetik, imunologi, dan lingkungan. Stres

Use of nicotinamide in dermatology

The evidence underlying the use of nicotinamide for various dermatological indications, including nonmelanoma cancer prophylaxis, blistering disorders, acne vulgaris and cosmetic indications, is reviewed, and its future role in dermatological practice is speculated upon.

Nicotinamide inhibits melanoma in vitro and in vivo

NAM shows a relevant anti-melanoma activity in vitro and in vivo and is a suitable candidate for further clinical investigations and shows for the first time that the expression levels of Niacin receptors HCAR2 and HCAR3 is almost abolished in human melanoma samples.

Maternal Nutritional Status and Development of Atopic Dermatitis in Their Offspring

No strong evidence indicates that a single nutrient or food in mothers’ diet significantly affects the risk of childhood AD, but mothers should not either increase nor avoid consuming these nutrients to prevent or ameliorate allergic diseases in their offspring.

Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months

  • S. El-HeisS. Crozier K. Godfrey
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2016
Nicotinamide, a naturally occurring nutrient that is maintained through the dietary intakes of vitamin B3 and tryptophan, has been used in the treatment of some skin conditions including atopic eczema.

Antioxidants in Sunscreens: Which and What For?

An up-to-date overview of the use of antioxidants in commercial sunscreens is provided for a better understanding of the advantages associated with their use in photoprotective formulations.

Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier

Nicotinamide improved the permeability barrier by stimulating de novo synthesis of ceramides, with upregulation of serine palmitoyltransferase (SPT) and other intercellular lipids.

Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes.

It is observed that while atRA upregulates AQP3 expression in cultured human skin keratinocytes (HaCaT cells), nicotinamide attenuates the effect of atRA in a concentration-dependent manner and decreases water permeability and water loss.

Safety of high-dose nicotinamide: a review

Experience to date suggests that the ratio of risk to benefit of long-term nicotinamide treatment would be highly favourable, should the drug prove efficacious in diabetes prevention, and high-dose Nicotinamide should still be considered as a drug with toxic potential at adult doses in excess of 3 gm/day and unsupervised use should be discouraged.

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.

Oral nicotinamide was safe and effective in reducing the rates of new nonmelanoma skin cancers and actinic keratoses in high-risk patients and there was no evidence of benefit after nicotinamide was discontinued.

Non-invasive evaluation of the kinetics of allergic and irritant contact dermatitis.

RCM, TEWL, and FES are valuable non-invasive tools to quantitatively study the kinetics of the pathophysiology of acute CD reactions in vivo and monitor the changes at a cellular level.

Nicotinamide and the skin

Nicotinamide shows promise for the treatment of a wide range of dermatological conditions, including autoimmune blistering disorders, acne, rosacea, ageing skin and atopic dermatitis, and is a potential agent for reducing actinic keratoses and preventing skin cancers.

Human stratum corneum lipids: characterization and regional variations.

The first detailed, quantitative analysis of human stratum corneum lipids and information about the variability in lipid composition at four skin sites with known differences in permeability suggest that variations in neutral lipids, rather than sphingolipids, may underlie local variations in skin permeability.

Changes in skin barrier function following long‐term treatment with moisturizers, a randomized controlled trial

This research focuses on the effects on skin barrier function of long‐term treatment with moisturizers in patients with dry skin conditions as well as people with healthy skin.

Variations of hair follicle size and distribution in different body sites.

The present investigation clearly contradicts former hypothesis that the amount of appendages of the total skin surface represents not more than 0.1% and leads to a differential evaluation of skin penetration processes and a completely different understanding of penetration of topically applied drugs and cosmetics.