Oral mucosal diseases: mucous membrane pemphigoid.

Abstract

Subepithelial vesiculobullous conditions are chronic autoimmune disorders that arise from reactions directed against components of the hemidesmosomes or basement membrane zones (BMZ) of stratified squamous epithelium to which the term immune-mediated subepithelial blistering diseases (IMSEBD) has been given. Mucous membrane pemphigoid (MMP) is the most common, but variants do exist. Non-immune disorders that involve these epithelial components typically have a genetic basis--the main example being epidermolysis bullosa. All subepithelial vesiculobullous disorders present as blisters and erosions, and diagnosis must be confirmed by biopsy examination with immunostaining, sometimes supplemented by other investigations. No single treatment reliably controls all subepithelial vesiculobullous disorders; the immunological differences within IMSEBD may account for differences in responses to treatment. Currently, as well as improving oral hygiene, immunomodulatory treatment is used to control the oral lesions of MMP, but it is not known if its specific subsets reliably respond to different agents.

020402008200920102011201220132014201520162017
Citations per Year

102 Citations

Semantic Scholar estimates that this publication has 102 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Scully2008OralMD, title={Oral mucosal diseases: mucous membrane pemphigoid.}, author={Crispian M Scully and Lorenzo Lo Muzio}, journal={The British journal of oral & maxillofacial surgery}, year={2008}, volume={46 5}, pages={358-66} }