Oral monoterpene therapy (perillyl alcohol) reduces vein graft intimal hyperplasia.

@article{Fulton1997OralMT,
  title={Oral monoterpene therapy (perillyl alcohol) reduces vein graft intimal hyperplasia.},
  author={Gregory J. Fulton and Lizzie Barber and Einar Svendsen and Per Otto Hagen and Mark G. Davies},
  journal={The Journal of surgical research},
  year={1997},
  volume={69 1},
  pages={
          128-34
        }
}
The development of intimal hyperplasia is recognized as a major impediment to graft patency. D-Limonenes are monoterpenes with a recognized cytostatic effect on cell proliferation by inhibiting posttranslational isoprenylation of p21ras and other small G-proteins. This study examines the effect of perillyl alcohol, an oral hydroxylated D-limonene, on the development of intimal hyperplasia and its associated smooth muscle cell physiological responses in an experimental model of vein bypass… Expand
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