• Corpus ID: 24909338

Oral manifestations of cyclic neutropenia in a Japanese child: case report with a 5-year follow-up.

@article{Nakai2003OralMO,
  title={Oral manifestations of cyclic neutropenia in a Japanese child: case report with a 5-year follow-up.},
  author={Yukie Nakai and Chikako Ishihara and Sagiri Ogata and Tsutomu Shimono},
  journal={Pediatric dentistry},
  year={2003},
  volume={25 4},
  pages={
          383-8
        }
}
Cyclic neutropenia is an uncommon hematologic disorder characterized by a marked decrease in the number of neutrophils in the peripheral blood occurring at regular intervals. [] Key Method Her case has been followed up for the past 5 years from age 7 to 12. The importance of regular oral hygiene, careful removal of subgingival plaque and calculus, and periodic and thorough professional mechanical tooth cleaning was emphasized to arrest the progress of periodontal breakdown.

Figures from this paper

Cyclic neutropenia presenting as recurrent oral ulcers and periodontitis.

Several clinical features help to differentiate CN from MaRAS and AP early recognition of the systemic cause of oral symptoms is important.

ORAL FINDINGS AND TREATMENT OF A PATIENT WITH CYCLIC NEUTROPENIA

The dental treatment, including regular tooth care and appropriate treatment of dental caries or gingivitis, is essential for patients suffering cyclic neutropenia and proper care at early stage is needed for young patients to minimize the unwanted consequences for permanent teeth development.

The Effect of Recombinant Granulocyte Colony-Stimulating Factor on Oral and Periodontal Manifestations in a Patient with Cyclic Neutropenia: A Case Report

In a 20-year-old Caucasian female with a diagnosis of cyclic neutropenia, oral clinical examination revealed multiple painful ulcerations of the oral mucosa, poor oral hygiene conditions, marginal gingivitis, and moderate periodontitis, the patient received a treatment with G-CSF in order to improve her immunological status.

Fraternal Twins with Cyclic Neutropenia: A Case Report of Full Dental Management

Dental treatment of 7-year-old fraternal twin girls diagnosed with cyclic neutropenia emphasized the importance of dental treatment for patients with compromised medical conditions and the oral cavity is a potential source of inflammation or infection.

Severe congenital cyclic neutropenia: A case report

A case report of a child with recurrent mouth ulcers, fever, and later diagnosed with severe congenital cyclic neutropenia is described, which emphasizes the importance of identification of rare causes of immunosuppressive conditions in children presenting with recurrent oral ulcers and poor dental hygiene.

Oral health comparison between children with neutropenia and healthy controls.

Preliminary data demonstrates that pediatric patients who are under the active care of a hematologist do not present with an increased risk of oral diseases.

Periodontal status of children with primary immunodeficiencies: a systematic review

The published literature suggests that patients with PIDs can present with severe periodontitis and that conventional treatment approaches have limited benefits.

Long-standing oral ulcers: proposal for a new 'S-C-D classification system'.

  • D. CompilatoN. Cirillo G. Campisi
  • Medicine
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • 2009
The authors suggest distinguishing simple, complex and destroying (S-C-D system) ulcerations, as each requires different diagnostic evaluations and management.

Cyclic neutropenia

The red herring of intrinsic and extrinsic sugars and their comparative cariogenicity appeared once again in the paper A comparison of the nutritional knowledge... (BDJ 2011; 210: 33-38).

Aggressive forms of periodontitis secondary to systemic disorders.

A selected group of systemic disorders that are associated with alterations in either neutrophil counts (quantitative disorders) or function (qualitative disorders), and defects in the mineralization of bone and dental tissues are reviewed.

References

SHOWING 1-10 OF 59 REFERENCES

Cyclic neutropenia: case report of two siblings.

The purpose of this case report is to describe the clinical and radiographic appearance of two children with cyclic neutropenia, and emphasize the need for repeated weekly blood studies to accurately diagnose the condition.

Long-term follow-up of periodontitis in a patient with Chédiak-Higashi syndrome. A case report.

A 21-year-old woman who presented at the age of 9 years with CHS and serious periodontal tissue destruction around erupted teeth is reported on, which was resistant toperiodontal treatment.

Prepubertal periodontitis affecting the deciduous and permanent dentition in a patient with cyclic neutropenia. A case report and discussion.

The report illustrates the importance of the laboratory assessment in dental patients with unusual periodontal destruction or other inexplicable oral changes, and the diagnosis of severe oral pathoses of obscure origin must include a differential white blood cell count.

Manifestations and treatment of periodontal disease in a patient suffering from cyclic neutropenia.

The result of the treatment of this patient shows that treatment, designed to eliminate plaque infection, is effective also in an individual with defective host defense against bacterial infections, but the demand on the patient's cooperation must be extraordinary high as well as the demands on the effectiveness of the maintenance care program.

Cyclic Neutropenia: An Unusual Disorder of Granulopoiesis Effectively Treated with Recombinant Granulocyte Colony‐Stimulating Factor

Treatment with daily recombinant granulocyte colony‐stimulating factor (rG‐CSF) resulted in a complete clearing of symptoms and a significant increase in quality of life in a 10‐year‐old boy with a classical presentation of CN that had remained undiagnosed for 10 years.

Periodontal disease in three siblings with familial neutropenia.

It was concluded that periodontal therapy including scaling, surgery, and use of antimicrobial agents can be successful in patients with familial neutropenia, and that such patients are not necessarily candidates for full mouth extraction.

The importance of regular dental treatment in patients with cyclic neutropenia. Follow-up of 2 cases.

Regular, monthly professional removal of dental plaque and calculus, and rinsing with 0.2% chlorhexidine gluconate during neutropenia help maintain periodontal attachment level.

Clinical periodontal findings and microflora profiles in children with chronic neutropenia under supervised oral hygiene.

Use of 1% povidone iodine solution and local antibiotic application under supervised oral hygiene were helpful to improve gingival conditions in patients with chronic neutropenia.

Absence of adult dental anomalies in familial hypophosphatasia.

L Laboratory blood and urine studies in conjunction with an analysis of periodontal microflora and family pedigrees established a diagnosis of hypophosphatasia in these 3 children, as well as their father, the paternal grandmother and paternal great-uncle.
...