Oral magnesium supplements decrease high blood pressure (SBP>155 mmHg) in hypertensive subjects on anti-hypertensive medications: a targeted meta-analysis.

@article{Rosanoff2013OralMS,
  title={Oral magnesium supplements decrease high blood pressure (SBP>155 mmHg) in hypertensive subjects on anti-hypertensive medications: a targeted meta-analysis.},
  author={Andrea Rosanoff and Michael Plesset},
  journal={Magnesium research},
  year={2013},
  volume={26 3},
  pages={
          93-9
        }
}
Previously, we examined 44 human studies involving oral magnesium (Mg) supplementation for hypertension (HT), sorting them according to HT status, Mg dose and anti-hypertensive medication usage. We found that while some studies reported a significant lowering of blood pressure with Mg supplementation, others did not. We present here our first meta-analysis of a uniform subset from this series of studies. Seven studies, involving 135 hypertensive subjects on anti-hypertensive medication… 

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References

SHOWING 1-10 OF 22 REFERENCES

The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial

Oral magnesium supplementation with MgCl2 significantly reduces SBP and DBP in diabetic hypertensive adults with hypomagnesaemia in a double-blind, placebo-controlled trial.

Does potassium supplementation lower blood pressure? A meta-analysis of published trials.

An increase in potassium intake should be included in the recommendations for a non-pharmacological approach to the control of blood pressure in uncomplicated essential hypertension.

Magnesium supplementation for the management of essential hypertension in adults.

The evidence in favour of a causal association between magnesium supplementation and blood pressure reduction is weak and is probably due to bias because poor quality studies generally tend to over-estimate the effects of treatment.

The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials.

Chronic magnesium administration enhances oxidative glucose metabolism in thiazide treated hypertensive patients.

In newly-diagnosed untreated and thiazide treated hypertensive patients erythrocyte ion content and plasma ion and metabolite levels were determined and chronic magnesium administration improved glucose uptake, glucose metabolic clearance rate, and oxidative glucose metabolism.

Role of magnesium in hypertension.

Promising hypotensive effect of hawthorn extract: A randomized double‐blind pilot study of mild, essential hypertension

There was a decline in both systolic and diastolic blood pressure in all treatment groups, including placebo, but ANOVA provided no evidence of difference between treatments, and factorial contrast analysis in ANOVA showed a promising reduction in the resting diastols at week 10 in the 19 subjects who were assigned to the hawthorn extract, compared with the other groups.

The cellular ionic basis of hypertension and allied clinical conditions.

  • L. Resnick
  • Medicine, Biology
    Progress in cardiovascular diseases
  • 1999