Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice

Abstract

Sublingual allergen-specific immunotherapy (SLIT) is a safe and efficacious treatment for type 1 respiratory allergies. Herein, we investigated the key subset(s) of antigen-presenting cells (APCs) involved in antigen/allergen capture and tolerance induction during SLIT. Following sublingual administration, fluorochrome-labeled ovalbumin (OVA) is… (More)
DOI: 10.1038/mi.2011.28

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