Oral lichen planus and malignant transformation: a longitudinal cohort study.

@article{Bombeccari2011OralLP,
  title={Oral lichen planus and malignant transformation: a longitudinal cohort study.},
  author={Gian Paolo Bombeccari and Gianpaolo Guzzi and Mauro Tettamanti and Aldo Bruno Giann{\`i} and Alessandro Baj and Francesco Pallotti and Francesco Spadari},
  journal={Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics},
  year={2011},
  volume={112 3},
  pages={328-34}
}
OBJECTIVE Oral lichen planus (OLP) is associated with risk for developing oral squamous cell carcinoma (OSCC). We performed a 7-year prospective study to assess the incidence of malignant transformation of OLP among adults. STUDY DESIGN Three hundred twenty-seven OLP patients, 229 women (70.0%) and 98 men (30.0%), were observed during the follow-up period. RESULTS During a mean follow-up of 81.7 months, 8 of 327 patients developed an OSCC in OLP areas (0.36%/y), yielding the high overall… CONTINUE READING

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