Oral ketamine and transdermal nitroglycerin as analgesic adjuvants to oral morphine therapy for cancer pain management.

@article{Lauretti1999OralKA,
  title={Oral ketamine and transdermal nitroglycerin as analgesic adjuvants to oral morphine therapy for cancer pain management.},
  author={Gabriela Rocha Lauretti and Izabel C P R Lima and Marlene Paulino dos Reis and Wiliam Alves Prado and Newton L Pereira},
  journal={Anesthesiology},
  year={1999},
  volume={90 6},
  pages={1528-33}
}
BACKGROUND Guidelines for cancer pain management include nonsteroidal antiinflammatory drugs with opioids administered in a time-contingent manner. This study was designed to evaluate the role of oral ketamine or transdermal nitroglycerin polymer, a nitric oxide donor, as coadjuvants to oral morphine in cancer pain therapy. METHODS After institutional approval and informed patient consent were obtained, 60 patients with cancer pain were randomized to one of four groups (n = 15) and studied… CONTINUE READING
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