Oral irritation by sodium chloride: sensitization, self-desensitization, and cross-sensitization to capsaicin

@article{Dessirier2001OralIB,
  title={Oral irritation by sodium chloride: sensitization, self-desensitization, and cross-sensitization to capsaicin},
  author={Jean Marc Dessirier and Michael O'Mahony and M Iodi-Carstens and Elisa C Yao and Earl E. Carstens},
  journal={Physiology \& Behavior},
  year={2001},
  volume={72},
  pages={317-324}
}
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References

SHOWING 1-10 OF 50 REFERENCES

Sensory properties of citric acid: psychophysical evidence for sensitization, self-desensitization, cross-desensitization and cross-stimulus-induced recovery following capsaicin.

The irritant sensation elicited by citric acid increased significantly, indicating a 'cross-stimulus-induced recovery' from capsaicin desensitization and involvement of vanilloid and acid-sensitive ion channels in acid-evoked irritation and pain is discussed.

Oral irritant effects of nicotine: psychophysical evidence for decreased sensation following repeated application and lack of cross-desensitization to capsaicin.

Psychophysical methods were used to assess changes in the intensity of irritant sensations elicited by repeated application of capsaicin and nicotine delivered unilaterally to the tongue of human subjects, indicating physiological mechanisms that might underlie the contrasting sensory effects of nicotine versus Capsaicin.

Oral irritant properties of piperine and nicotine: psychophysical evidence for asymmetrical desensitization effects.

Using a bipolar rating scale, human subjects rated the intensity of irritation sensation evoked by repeated application of piperine or nicotine to one side of the dorsal surface of the tongue to form an asymmetrical cross-desensitization pattern similar to that observed between capsaicin and nicotine.

Sensitization and desensitization to capsaicin and menthol in the oral cavity: Interactions and individual differences

Desensitization to Oral Zingerone Irritation: Effects of Stimulus Parameters

Capsaicin sensitization and desensitization on the tongue produced by brief exposures to a low concentration

  • B. Green
  • Psychology
    Neuroscience Letters
  • 1989

Rapid recovery from capsaicin desensitization during recurrent stimulation

Evidence that removal of capsaicin accelerates desensitization on the tongue

  • B. Green
  • Psychology, Biology
    Neuroscience Letters
  • 1993

Temporal characteristics of capsaicin sensitization and desensitization on the tongue

  • B. Green
  • Psychology
    Physiology & Behavior
  • 1991

Interactions between oral chemical irritation, taste and temperature

The oral chemical irritant, capsaicin, at 2, 4 and 8 p.p.m., was combined in mixtures with sucrose (Experiment 1), sodium chloride (Experiment 2) and soup (Experiment 3), each evaluated at two…