Oral irritation by sodium chloride: sensitization, self-desensitization, and cross-sensitization to capsaicin

  title={Oral irritation by sodium chloride: sensitization, self-desensitization, and cross-sensitization to capsaicin},
  author={Jean Marc Dessirier and Michael O'Mahony and M Iodi-Carstens and Elisa C Yao and Earl E. Carstens},
  journal={Physiology \& Behavior},

Oral irritation by mustard oil: self-desensitization and cross-desensitization with capsaicin.

The temporal patterns of oral irritation exhibited by mustard oil, and its reciprocal cross-desensitization with capsaicin, are similar to those of menthol and nicotine.

Selective Effects of Temperature on the Sensory Irritation but not Taste of NaCl and Citric Acid

The results are consistent with involvement of the heat-sensitive channel TRPV1 in the sensory irritation of both stimuli together with one or more additional channels (e.g., acid-sensing channel, epithelial sodium channel, TRPA1) that are insensitive to heat and may possibly be sensitive to cooling.

Psychophysical Evaluation of a Sanshool Derivative (Alkylamide) and the Elucidation of Mechanisms Subserving Tingle

Results show that lingual alkylamide evokes a complex sensation that is temporally dynamic and consistent with in vitro and in vivo experiments suggesting these compounds activate mechanosensitve neurons via blockade of KCNK two-pore potassium channels to induce the novel tingling sensation.

Oral Chemesthesis and Taste

The orotrigeminal system.

  • A. Klein
  • Biology
    Handbook of clinical neurology
  • 2019



Sensory properties of citric acid: psychophysical evidence for sensitization, self-desensitization, cross-desensitization and cross-stimulus-induced recovery following capsaicin.

The irritant sensation elicited by citric acid increased significantly, indicating a 'cross-stimulus-induced recovery' from capsaicin desensitization and involvement of vanilloid and acid-sensitive ion channels in acid-evoked irritation and pain is discussed.

Oral irritant effects of nicotine: psychophysical evidence for decreased sensation following repeated application and lack of cross-desensitization to capsaicin.

Psychophysical methods were used to assess changes in the intensity of irritant sensations elicited by repeated application of capsaicin and nicotine delivered unilaterally to the tongue of human subjects, indicating physiological mechanisms that might underlie the contrasting sensory effects of nicotine versus Capsaicin.

Oral irritant properties of piperine and nicotine: psychophysical evidence for asymmetrical desensitization effects.

Using a bipolar rating scale, human subjects rated the intensity of irritation sensation evoked by repeated application of piperine or nicotine to one side of the dorsal surface of the tongue to form an asymmetrical cross-desensitization pattern similar to that observed between capsaicin and nicotine.

Interactions between oral chemical irritation, taste and temperature

The oral chemical irritant, capsaicin, at 2, 4 and 8 p.p.m., was combined in mixtures with sucrose (Experiment 1), sodium chloride (Experiment 2) and soup (Experiment 3), each evaluated at two