Oral infection, hyperglycemia, and endothelial dysfunction.

  title={Oral infection, hyperglycemia, and endothelial dysfunction.},
  author={S-J Janket and Judith A. Jones and Jukka H Meurman and Alison E. Baird and Thomas E Van Dyke},
  journal={Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics},
  volume={105 2},
Metabolic syndrome and type 2 diabetes (T2DM) resulting from sustained hyperglycemia are considered as risk factors for cardiovascular disease (CVD) but the mechanism for their contribution to cardiopathogenesis is not well understood. Hyperglycemia induces nonenzymatic glycation of protein-yielding advanced glycation end products (AGE), which are postulated to stimulate interleukin-6 (IL-6) expression, triggering the liver to secrete tissue necrosis factor alpha (TNF-alpha) and C-reactive… CONTINUE READING