Oral immunotherapy for food allergy

@article{Vickery2010OralIF,
  title={Oral immunotherapy for food allergy},
  author={Brian P. Vickery and Wesley A. Burks},
  journal={Current Opinion in Pediatrics},
  year={2010},
  volume={22},
  pages={765–770}
}
Purpose of review Food allergy is a difficult clinical problem for which no disease-modifying therapy currently exists. Recent findings The daily administration of graded allergen doses through oral immunotherapy (OIT) is one promising experimental approach to the development of a clinically available treatment. Although the concept of oral immunologic tolerance is not new, OIT as a treatment for food allergy is innovative. Over the last few years, several groups of investigators have begun to… 
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62 Citations
Highly Influential Citations
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Background Citations
22
Methods Citations
2
Results Citations
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62 Citations

Citation Type

Citation Type

Oral Immunotherapy for Food-Allergic Children: A Pro-Con Debate
TLDR
OIT remains a controversial therapy and no definitive generalized conclusion may be drawn so far, but it should be an option provided by specialized teams, when both patients and their families are prone to adhere to the proposed protocol.
IgE-mediated food allergy
TLDR
The mechanism of IgE-mediated food allergy is better understood but further research is needed to prevent and treat food allergies.
Combining anti‐IgE with oral immunotherapy
  • Chunrong Lin, Ivan T Lee, +4 authors K. Nadeau
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2017
TLDR
Results from several trials have shown that the addition of omalizumab to OIT leads to a significant decrease in the frequency and severity of reactions, which allows for an increase in the threshold of tolerance to food allergens.
Biologics in food allergy: up-to-date
TLDR
The role of biologics as a treatment option in patients with IgE-mediated food allergy is focused on, characterized by their ability to inactivate the Th2 pro-inflammatory pathways.
Food Allergy: What We Know Now.
Next-Generation Approaches for the Treatment of Food Allergy
TLDR
A review of novel approaches to the treatment of food allergy that are currently under investigation, including the use of SLIT, modified proteins, probiotics, Chinese herbal supplements, biologic therapies, and DNA vaccines.
Food Allergy: Present and Future Management
TLDR
There are multiple clinical and murine models of food allergy treatment that use allergen specific and nonspecific pathways and these methods may be useful for those patients with multiple food allergies.
Immunological mechanisms for desensitization and tolerance in food allergy
TLDR
Additional studies are required to elucidate and understand the mechanisms by which desensitization and tolerance are achieved, which may reveal valuable biomarkers for evaluating and following food allergic patients on immunotherapy.
Oral Immunotherapy in Children: Clinical Considerations and Practical Management
TLDR
Clinical considerations for OIT in pediatrics are discussed, including efficacy and safety, practical management, and future directions of treatment.
Is oral immunotherapy the cure for food allergies?
TLDR
Preliminary data on OIT are encouraging, but additional studies must answer multiple questions including optimal dose, ideal duration of oral/sublingual immunotherapy, degree of protection, efficacy for different ages, severity and type of food allergy responsive to treatment and need for patient protection during home administration.
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