Oral immunogenicity of the plant proteinase bromelain.

  title={Oral immunogenicity of the plant proteinase bromelain.},
  author={Laura P. Hale and David J. Fitzhugh and Herman F Staats},
  journal={International immunopharmacology},
  volume={6 13-14},
Bromelain is a natural mixture of proteolytic enzymes derived from pineapple stem that has been shown to have anti-inflammatory activity when administered orally. Although most proteins given orally without adjuvant (e.g., food) result in tolerance, we previously reported that long-term oral exposure to bromelain stimulated the development of high serum anti-bromelain antibody titers. The purpose of these studies was to further investigate the mechanisms responsible for the immunogenicity of… CONTINUE READING
Highly Cited
This paper has 24 citations. REVIEW CITATIONS