Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches.

@article{Nakagawa1996OralIW,
  title={Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches.},
  author={Ichiro Nakagawa and Ichiro Takahashi and Hiroshi Kiyono and Jerry R. Mcghee and Shigeyuki Hamada},
  journal={The Journal of infectious diseases},
  year={1996},
  volume={173 6},
  pages={1428-36}
}
The B subunit of heat-labile toxin (LT-B) from enterotoxigenic Escherichia coli has been shown to be a powerful mucosal immunogen. Oral immunization of mice with LT-B revealed that BALB/c (H-2d) and C57BL/6 (H-2b) mice gave high serum IgG and mucosal IgA responses specific for LT-B. However, ALY (H-2b) mice lacking intestinal Peyer's patches (PP) did not… CONTINUE READING